Methyl 4-bromocrotonate, CAS 1117-71-1, English name is methyl 4-bromocrotonate.
It is a useful synthesis intermediate. It is used in the synthesis of irreversible inhibitors of EGFR and HER-2 tyrosine kinases with enhanced antitumor activity.
Basic parameters of methyl 4-bromocrotonate:
Chinese name: methyl 4-bromocrotonate.
Catalog number: 1062580
English name: methyl 4-bromocrotonate
Synonyms: Methyl 4-bromocrotonate (CAS number: 1117-71-1);methyl bromo crotonate
CAS Number: 1117-71-1
MDL number: MFCD00000246
Purity: 88%.
Molecular formula: C5H7BRO2
Molecular weight: 17901
Structural Formula:
Chemical reagent: Leyan reagent.
Storage conditions: store at room temperature
Boiling Point: 83-85°C at 760 mmHg;Flash Point: 92°C
Safety information of methyl 4-bromocrotonate:
Warning word: danger
Hazard Statement: H315-H318-H335
Warning: p261-p280-p305+p351+p338
GHS code: GHS05, GHS07
UN Code: 1760
Hazard Category: 8
Packaging Grade:
Methyl 4-bromocrotonate synthesis route:
Synthetic route: 623-43-8 1117-71-1
References: Houllemare, Didier; outurquin, francis; paulmier, claude journal of the chemical society - perkin transactions 1, 1997 , # 11 p. 1629 - 1632
Synthetic route: 3724-65-0 1117-71-1
References: Pullin, Robert D c.; rathi, akshat h.; melikhova, ekaterina y.; winter, christian; thompson, amber l.; donohoe, timothy j. organic letters, 2013 , vol. 15, # 21 p. 5492 - 5495
Synthetic route: 623-43-8 1117-71-1 56699-18-4
References: organic letters, vol 16, # 5 p. 1438 - 1441
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