Shenzhen News Network, December 22, 2023 (Reporter Lu Dongbo, Correspondent Wang Zhuofen, Yu Yuan) "There is no shortcut to being a doctor, that is, you have to pay steadily", "Scientific research in the medical field should come from the clinic and return to the clinic", "The achievement of any scientific research results comes from persistence......".
On December 19, the 2023 Annual Awards Conference of Ho Leung Ho Li was held in Beijing, and Pei Guoxian, President of Southern University of Science and Technology Hospital and Chair Professor of Southern University of Science and Technology, won the "Science and Technology Progress Award". On the 21st, after returning to Shenzhen from Beijing, he was interviewed by reporters, talking about his experience in clinical, scientific research and teaching for 50 years, as well as suggestions for the growth of young doctors.
From hygienist to clinical research "double" star.
Pei Guoxian joined the army at a young age and was a company health officer. Now it seems that the professional starting point is not very high, and this has become a place where many colleagues and students worship him. "From hygienist to MD, clinical expert, to academic star, this is an inspirational story," said Li Sijing, a PhD student. True success isn't about where you start, it's about how far you can go. Professor Pei's experience and achievements can give people strong spiritual strength. ”
When he was young in the army, Pei Guoxian witnessed many patients with severe limb injuries and comrades-in-arms with limb injuries forced to amputate their limbs.
In the early 90s of the 20th century, Pei Guoxian, then 36 years old, was already the director of the Hand Surgery Center of the 153rd Central Hospital of the People's Liberation Army. One day, he saw a special patient. This patient was cut off his hands and feet by his brother because of a family dispute, and his injuries were terrible. According to the analysis of the injury, a rescue team of 15 people was quickly formed, and 4 surgeries were carried out at the same time. After more than 9 hours, all the limbs of the injured person, who had been ischemic for 22 hours and 30 minutes, were revived, and the patient's limbs recovered well. Academician Chen Zhongwei, who is known as the "father of finger replantation in the world", spoke highly of it: "This is a miracle in the history of trauma surgery and fills a gap in the field of trauma surgery. ”
In 2000 and 2001, Pei Guoxian took the lead in successfully carrying out 2 cases of allogeneic single-handed transplantation (the first case in the world) and 1 case of allogeneic double forearm transplantation in Asia, creating a precedent for allogeneic limb transplantation in Asia, and was known as the first person in Asia to transplant allogeneic limbs, and his research results were awarded the "Top Ten News of Chinese Medical Science and Technology" in 2000.
The clinical problem is the direction of my scientific research".
Although there are many patients who have successfully replanted their limbs, there are many more patients with bone defects that do not even have the opportunity to be transplantedThe problems that arise in clinical practice are the direction of my scientific research. ”
Pei Guoxian recalled that in the 90s of the 20th century, the repair of large bone defects was still a worldwide problem in the field of orthopedics. With the support of the National Natural Science Key Project, since 1996, he has led the team to conduct a series of studies on the innovative repair of large bone defects, including seed cell screening, cell culture, biomaterial screening and preparation, cell material complex formation, in vivo implantation, vascular neurochemistry and osteogenic mechanism, etc., and has achieved clinical transformation.
Medical research must come from the clinic, return to the clinic, and serve patients. Pei Guoxian's research and scientific research on the repair of large bone defects have ultimately benefited many patients.
Kong Jun (pseudonym), a 35-year-old boy from Gansu, was the first lucky winner. In 2015, he was run over by a tractor in an accident, suffering an open fracture of his leg and a 12-centimeter defect in his tibia. After many medical treatments, the doctor gave several options: either amputation and then fitting a prosthesis;Either a bone substitute such as a traditional mechanical prosthesis is implanted in the leg. "It must be original!Pei Guoxian's team used the most advanced tissue engineering technology to customize tissue engineering regenerated bone with living cells according to the shape and size of the patient's bone defect in vitro, and "regenerated" the defective tibia for Kong Jun. After 3 months of surgery, Kong Jun was able to walk on crutches and after 6 months, he threw away the crutches and was able to bear weightAfter 12 months, the external fixation brace for the leg was removed, and walking and jumping were normal;After 22 months, you can walk briskly, climb and descend stairs and lift heavy objects.
This is also the world's first case of weight-bearing bone defect with a length of more than 12 cm repaired by tissue engineering regenerative bone technology, which is an important beginning of tissue engineering bone regenerative medicine technology from the laboratory to clinical application, and has achieved a major breakthrough in the global problem of large bone defect repair.
It pioneered the new operation of "double bridge transplantation" to avoid amputation of patients with lower limb disfiguring trauma, and the limb salvage rate increased from 230% rose to 911%；It is the first to create anti-infective active bone repair technology, so that patients with bone defect infection can achieve simultaneous repair and speed up the repair processThe first 3D printed prosthesis bionic repair technology enables patients with ultra-long bone defects to have bionic limbs and move more freely ......Pei Guoxian and his team's series of research results have been promoted and applied in 386 hospitals, benefiting countless patients.
There is no secret to the achievement of results, only persistence".
The pioneering and innovative in the field of clinical and scientific research has made Pei Guoxian a "big award-win" - the first and second prizes of the National Science and Technology Progress Award, the first prize of the Natural Science Award of the Ministry of Education, the first prize of the Provincial Army, and the ...... of the Ho Liang Ho Li Award
Professor Pei Guoxian won the first prize of the National Science and Technology Progress Award in 2020. ）
Repeatedly achieved results, Pei Guoxian said that there is no "secret", only "persistence". "It's like climbing a mountain, you feel that it's tough, but if you keep going, you can climb higher and see farther. ”
Pei Guoxian, who is looking far away, has a broader vision and a sharper thinking. With the development of digital information, the combination of medicine and engineering between digitalization and orthopedics has great potential and application prospects. Having been a surgeon for decades, he understands the pain point of traditional surgery and has a keen grasp of the disruptive changes that digital intelligence technology can bring to the medical field. In 2006, Pei Guoxian proposed the concept of "digital orthopedics", which opened up the emerging interdisciplinary discipline "digital orthopedics" in the world. He led the establishment of China's digital orthopedic academic organization, actively promoted the clinical transformation and application of digital orthopedics, and promoted China's digital orthopedic technology to quickly rank among the international frontiers.
In Shenzhen, a hot land of innovation, Pei Guoxian deeply cross-integrates artificial intelligence and 3D printing into clinical medicine. Under his leadership, the Department of Orthopaedics of Southern University of Science and Technology Hospital has successfully carried out cutting-edge technologies such as the world's first mixed reality (MR) navigation spine surgery and the country's first O-arm-assisted Dimensity robotic spine surgery. Southern University of Science and Technology Hospital became the first hospital in South China to exceed 100 O-arm-assisted Dimensity robotic surgeries, ranking first in South China in terms of the number of completed cases. Intelligent, minimally invasive, and precise surgery has benefited more patients.
The Guangdong-Hong Kong-Macao Intelligent Medical Innovation Research Institute of Southern University of Science and Technology, founded by Pei Guoxian, has become an important transformation platform for intelligent medical innovation and high-tech in the Greater Bay Area.
To be a doctor is to be able to bear the trust of life".
Cultivating high-level medical-engineering interdisciplinary talents who can support technological updates and iterations is also an important task for Pei Guoxian. He has set up cutting-edge medical courses such as "Microsurgical Technology", "Regenerative Medicine" and "Intelligent Medicine", and has successively trained 9 postdoctoral fellows, 78 doctoral students, and 56 master's students, cultivating a group of high-level compound innovative talents in the field of orthopedics for the country.
Whether young people want to practice medicine or not, they must follow their hearts and start from their interests. After 50 years of medical practice, Pei Guoxian sighed: "First of all, you have to be interested, and if you are interested, you will be half the success;Secondly, you have to keep learning, technology is changing with each passing day, and being a doctor means lifelong learning;Third, you have to pay, there is no shortcut to the road of medicine, you must walk steadfastly and willingly. Pei Guoxian said that being a doctor means dealing with life, and a little carelessness may cause pain, disability, and even death to patients, so it is necessary to be able to afford the trust of life.
Pei Guoxian's road to medicine is arduous and scenic all the way. This "award-winning household" also has many honors - he has been awarded national experts with outstanding contributions, experts with special allowances, the first national young and middle-aged medical science and technology star, military science and technology gold star, the first batch of candidates for the national millions of talents project, and senior experts directly contacted by the organization department. In 2023, he was also elected as a valid candidate for co-optation of academicians of the Chinese Academy of Sciences.