The *** of furosemide is mainly related to water and electrolyte imbalances, especially in high doses or long-term use. The details are as follows:
Electrolyte abnormalities: common in hypokalemia, hyponatremia, and hypochloremic alkalosis.
Adverse reactions such as mild nausea, diarrhea, drug rash, itching, and blurred vision may occur.
Orthostatic dizziness, fatigue, tiredness, muscle cramps, thirst, and a few cases will have leukopenia, occasionally liver damage, thrombocytopenia, granulocytopenia, hepatitis, and even hepatic coma, erythema multiforme, etc.
Long-term use of furosemide can also cause adverse reactions such as hyperuricemia, gastrointestinal barrier, allergic reactions, increased blood sugar, and duodenal ulcer.
Therefore, the use of furosemide should be noted to start with a small dose, and gradually adjust the dose according to the response after the drug to reduce the occurrence of water and electrolyte disorders. During the medication, attention should be paid to monitoring blood electrolytes, pH value, blood pressure, blood glucose and blood uric acid. Attention should be paid to potassium supplementation for long-term and/or high-dose medication to avoid hypokalemia. Because furosemide can affect blood uric acid and blood glucose levels, for patients with diabetes and hyperuricemia, attention should be paid to appropriately adjusting the dose of hypoglycemic drugs and urate-lowering drugs during medication.
The above information is for reference only, it is recommended to consult a doctor if necessary.