Hyaluronic acid also has applications in medical dressings. Due to its moisturizing and wound-promoting properties, hyaluronic acid is often used to make dressings to speed up wound healing and reduce scarring. Hyaluronic acid dressings can be used for the ** and protection of various wounds, burns, ulcers and other wounds.
As a medical dressing, the molecular weight of HA affects its physicochemical properties and biological activity.
1.Low molecular weight HA (<500 kDa): Low molecular weight HA is typically obtained by enzymatic digestion or radiation degradation of high molecular weight HA. Low molecular weight HA has high biological activity and can stimulate cell proliferation and migrationPromotes wound healing。In addition, low molecular weight HA has:Anti-inflammatory and antioxidantrole.
2.Medium molecular weight HA (500-1000 kDa): Medium molecular weight HA inMoisturizes and promotes wound healingIt has a good effect, and can also provide a certain anti-inflammatory effect.
3.High molecular weight HA (>1000 kDa): High molecular weight HA has a goodAdhesion and moisturizing, which can form a protective layer to prevent wound infection. However, its biological activity is relatively low, and its promotion effect on wound healing is also weak.
The molecular weight of HA is an important consideration when choosing a medical dressing. In general, for wounds that require rapid healing and anti-inflammatory, low-molecular-weight HA;For wounds that require long-term moisturization and protection against infection, high molecular weight HA can be chosen. In fact, many commercial medical dressings use composites that blend different molecular weight HAs to combine their respective advantages.