The phototoxic effect of phototoxic chemicals has led to more and more attention, and with the increasing number of cosmetics on the market, it is necessary to conduct phototoxicity tests on cosmetics.
Phototoxicity is the absorption of light quanta by phototoxic substances, and then the energy is transferred to surrounding molecules, causing cell damage. Long-wave UVA activates many phototoxic substances, but some phototoxic substances can absorb medium-wave UVB and cause **toxic reactions. In general, medium and long-wave ultraviolet lamps are used for experiments, and the UVA and UVB contents are 528% and 168%。The results of the experiment showed that the irradiation dose reached 193 joules, and then controlled and tested to see if the test object produces a phototoxic reaction.
The degree of phototoxicity is related to the dose of light energy and the quality of the phototoxicant. Therefore, for the cosmetics to be tested, the irradiation dose should be as large as possible during the detection to increase the detection level of phototoxicity of the cosmetics to be tested, so as to increase the safety factor of the cosmetics to be tested.
The main biological function of UVA is tanning, and it takes a long time for the light in this spectral range to cause the erythema reaction, and the main biological role of UVB is to produce erythema, and the time required for the light in this spectral range to cause the erythema reaction is shorter, so choosing an ultraviolet lamp with low UVB content and high UVA content can increase the MED value and thus increase the irradiation dose, and then improve the detection level of this experimental method. In addition, increasing the amount of cosmetics to be tested can also be conducive to detecting the phototoxicity of the cosmetics to be tested without causing primary irritation.
Luyor has developed a special equipment for phototoxicity testing, Luyor-3450 cell phototoxicity irradiation instrument, before that, the phototoxicity test needs to use UVA + UVB ultraviolet lamp to irradiate the test object, this method can not monitor the ultraviolet intensity in real time, and the ultraviolet energy control of the control radiation is not accurate enough, so it will have a certain impact on the experimental results. The Luyor-3450 Cellular Phototoxicity Irradiation Meter perfectly solves these problems, and can complete the ultraviolet irradiation experiment completely autonomously, and automatically stop after the ultraviolet energy reaches without manual operation. The luyor-3450 device greatly changes the inconvenience of phototoxicity testing, making this test easier and faster.