In the previous article, I learned about the problem of occipital baldness in infants and young children when vitamin deficiency is deficient, so what will be the best manifestations if there is too much vitamin D?
Dietary intake of vitamin D rarely causes overdose, but excessive vitamin D supplementation, or drinking milk fortified with high levels of vitamin D3, prolonged high-dose vitamin D preparations (calcitriol)** hypoparathyroidism, vitamin D-resistant rickets, renal osteodystrophy, and osteoporosis, vitamin D** non-vitamin D-deficient disorders such as lupus vulgaris, rheumatoid arthritis, and psoriasis (large areas of calcipotriol or catarrhalst) can cause vitamin D toxicity.
Some scholars believe that a daily intake of 2000 IU of vitamin D can cause poisoning, but the poisoned person may be sensitive to vitamin D, but a long-term daily intake of 5000 IU will inevitably cause poisoning. At present, it is believed that due to the unrestricted metabolism of vitamin D2 to 25(OH)2D3 by the liver, its plasma level is too high, which strongly stimulates intestinal calcium absorption and bone calcium mobilization, and also causes a large amount of phosphorus absorption and produces poisoning symptoms.
Laboratory tests show an increase in urinary calcium, and a serum calcium level of 288 mmol l, (normal reference value is 2.)02~2.67 mmol L), serum phosphorus level at 162 mmol L or more (normal reference value is 0.)80~1.60 mmol l) ECG shows shortened QT interval and arrhythmia, and x-ray shows osteofibrous osteitis, **, and visceral tissue calcification.
The main clinical symptoms are valve force, headache, loss of appetite, weight loss, polydipsia, nocturia, careful vomiting, abdominal pain, stool, decreased muscle tone, tachycardia and arrhythmia, itching and acne-like manifestations over time, calcification and tissue destruction of soft tissues, large blood vessels, heart, lungs, and kidney tissues, and metastatic calcium deposits are mostly located near the buttocks, extremities, and joints. There are nodules and calcifications in the kidneys, and even kidney failure, and in severe cases, fever, coma, and even death.
Once the diagnosis is confirmed, patients should immediately stop taking vitamin D, eat a low-calcium diet, and drink plenty of fluids. Calcium excretion is increased with a furaline diuretic, and serum calcium is at 3Glucocorticoids can be used above 75 mmol, diuretics are discontinued when blood calcium returns to normal levels, and blood calcium remains normal for 2-3 months. Tapering and stopping glucocorticoids.
To sum up, taking too much vitamin D can cause problems such as: itching, acne-like manifestations, metastatic calcium deposition, and so on. Therefore, no matter what kind of medicine it is, it should not be taken in excess, otherwise it will cause unpredictable consequences to the human body.
Vitamins