MAL-PEG5-OH, maleimide-pentaethylene glycol-hydroxy.
Product Name: MAL-PEG5-OH
Chinese name: maleimide-pentaethylene glycol-hydroxy.
Purity: 95%+
Storage conditions: -20°C, protect from light and moisture.
Appearance: Solid or liquid, depending on molecular weight.
Linker is an important structure that connects the two active groups of Protac drugs, and plays a crucial role in the activity, metabolic stability and pharmacokinetic properties of ProTAC molecules.
In addition to the structure of the linker, its junction site also affects the selectivity and activity of the Protac. The general principle of selection of junction sites is as follows:
1) does not reduce the binding capacity between the E3 ligase ligand or POI ligand and its receptor;
2) Select the solvent exposure area of the ligand binding pocket;
3) Try to ensure the integrity of the POI ligand when connecting the linker to avoid affecting its binding ability. Figure 5 lists the common ligation sites for the E3 ligase ligand (red arrows) as well as the ligation sites for several POI ligands.
Product: cy5-peg5-azide
cy5-peg3-azide
bis-(n,n'-amine-peg3)-cy5 cas:2107273-36-7
n-(m-peg4)-n'-(amino-peg3)-cy5 cas:2107272-96-6
cy5-peg5-amine hcl salt
n,n'-bis-(propargyl-peg4)-cy5 cas:2107273-08-3
n-(m-peg4)-n'-(m-peg4)-o-(m-peg4)-o'-(propargyl-peg4)-cy5 cas:2107273-54-9
n-methyl-n'-methyl-o-(m-peg4)-o'-(propargyl-peg4)-cy5 cas:2107273-50-5
It is for scientific research only and cannot be used for human experiments2023.11.17