Rosuvastatin is aPowerful statins, whose main role is to block cholesterol synthesis by inhibiting HMG-Coa reductase. HMG-Coa reductase is a rate-limiting enzyme for cholesterol synthesis, and by inhibiting its activity, rosuvastatin can reduce plasma cholesterol and low-density lipoprotein (LDL) levels.
Rosuvastatin has a very strong lipid-lowering effect, which can significantly reduce LDL cholesterol levels, and also has a certain lowering effect on total cholesterol and triglycerides. Studies have shown that:Rosuvastatin can reduce LDL cholesterol levels by 20% to 60% and has a significant lipid-lowering effect.
In addition, rosuvastatin may also shrink plaques in a small number of people, which is also of great significance for the prevention of atherosclerosis and cardiovascular diseases.
And yet it isDrugs are all poisonousRosuvastatin may also pose some potential risks to certain populations. In clinical practice, we strongly recommend that the following five groups of people do not take rosuvastatin. Here's why and what we recommend::
1.Patients with abnormal liver function:The liver damage of statins is usually related to the lipid-lowering strength and dose of the drug. As a potent lipid-lowering drug, long-term use of rosuvastatin may cause liver damage. Therefore, while taking rosuvastatin, liver function tests need to be done regularly. If the aminotransferase level is within 3 times, a dose reduction or change to another drug may be consideredIf aminotransferase levelsMore than 3 times, it is recommended to discontinue rosuvastatin. If the lipid-lowering effect of rosuvastatin 10 mg is not good, the combination of ezetimibe or PCD90 drugs can be considered, and 20 mg should not be intensified, so that the dose is increased by 1 time, and the lipid-lowering intensity is only increased by 6%.
For patients with abnormal liver function, especially those with liver disease, it is true that extra caution is required when taking rosuvastatin. Rosuvastatin is primarily metabolized by the liver, so patients may face impaired drug metabolism and excretion, resulting in increased drug accumulation in the body, thereby increasing the risk of adverse effects.
2.Patients with muscle diseases:Rosuvastatin may cause muscle disorders such as muscle pain, muscle weakness and myofibrous membrane disease. If you have a muscle disorder, taking rosuvastatin can make it worse. Rosuvastatin may cause adverse effects in people with muscle disorders, including but not limited to muscle pain, muscle weakness, and myofibrous membrane disease. Therefore, if you suffer from muscle diseases, especially muscle enzymes that are more than 10 times, avoid taking rosuvastatin to avoid aggravating the condition.
3.Alcohol abusers:Alcohol abuse can cause damage to the liver. Because rosuvastatin is primarily metabolized in the liver, alcohol abusers may increase the risk of liver damage when using the drug. Alcohol abusers are advised to reduce or avoid alcohol and discuss other lipid-lowering alternatives with their doctor.
4.Pregnant and lactating women:Rosuvastatin may have adverse effects on the fetus, so pregnant and breastfeeding women should avoid the drug. If you're planning to become pregnant or breastfeeding, talk to your doctor about other safe ways to lower your lipids.
5.Patients with a history of allergies:As with other medications, rosuvastatin may have an allergic reaction in some people. If you're allergic to rosuvastatin or other statins, talk to your doctor and seek alternative** options.
Although rosuvastatin is a very effective lipid-lowering drug that reduces the risk of cardiovascular disease, it may pose additional risks for all five groups of people mentioned above.