I am a white-collar worker with a lot of work pressure, often staying up late and working overtime, facing high work pressure and tight deadlines. In pursuit of professional success, I often worked late into the night and juggled various urgent tasks.
These stresses started to affect the quality of my sleep, with sleep disturbances and lack of energy during the day. Start trying to change your habits, maintain a regular sleep schedule, and avoid excessive use of electronic devices. Try relaxation techniques to reduce anxiety and stress. But it still doesn't completely solve my sleep problems.
I heard from a friend that dexzopiclone and zopiclone can lead to insomnia," the patient said. Today, I will talk to you about the difference between these two drugs, and will this drug be addictive?Which effect and**how.
Insomnia is a sleep disorder in which you can't fall asleep or stay asleep enough, causing you to feel tired and lack of energy during the day. Insomnia can generally be divided into three types:
1.Sleep onset disorder insomnia, 2Maintenance disorder insomnia, 3Early awakening insomnia.
Dexzopiclone and zopiclone are both non-benzodiazepine sedative-hypnotic drugs
Most people have a hard time distinguishing between the two drugs, and some even think that they are the same one, but they are actually both similar and very different.
First of all, from a structural point of view,Zopiclone has two enantiomers, left-handed (R) and right-handed (S), and right-zopiclone is the right-handed isomer of zopiclone
WhileDextrol isomers that exert their effects, their mechanism of action is similar, and both enhance neurodepressive effects by activating GABA receptors, resulting in sedative, hypnotic, and anxiolytic effects. However, the affinity of dexzopiclone is 50 times higher than that of zopiclone, so the effect is stronger, and levorotator may increase the risk of adverse drug reactions. Therefore, Dexzopiclone can be considered an upgraded version of Zopiclone, but inAdvantages in terms of potency and ***
However, being effective doesn't necessarily mean better. Evaluating the advantages and disadvantages of drugs also requires a comprehensive evaluation from multiple aspects such as speed of onset, duration of action, safety, and drug dependence.
1. Peak time of blood concentration:The plasma concentration of dexzopiclone peaks faster than zopiclone, reaching a peak of 1 hour, compared to 15-2 hours. Dexzopiclone is slightly better because it theoretically works faster and works better.
2. Duration of the drug:The clearance half-life of zopiclone is generally 5 hours, and it is extended to 7 hours in older people;Dexzopiclone is generally 6 hours, and in the elderly it is extended to 9 hours. A short duration of action may lead to sleep deprivation, however, an excessively long duration of action may lead to "".Hangovers"The phenomenon that affects daytime life and work,Falls may be at risk especially for older people。Therefore, it is more important to choose the right medication according to the individual situation, especially for the elderly, the recommended average sleep time is 6-8 hours, thereforeZopiclone is more suitable
3.Usual Dosage:The usual dosage of dexzopiclone and zopiclone is slightly different, and dexzopiclone has 1mg, 2mg, and 3mg depending on the degree of sleep disorder, while the usual dose of zopiclone is 375mg and 75mg。Dexzopiclone is more abundant and more suitable for the elderly from small doses to be adjusted slowly.
4.Security:Dexzopiclone tablets are advantageous due to their higher affinity for central benzodiazepine receptors. Compared to zopiclone, the half-lethal dose of dexzopiclone tablets was significantly increased, which means that the efficacy is improved while the toxicity is reduced. Therefore, dexzopiclone tablets do a better job in guaranteeing safety.
5.*Aspects:Zopiclone has a slight advantage over right zopiclone.
Precautions for use:
1.Use thisAlcohol is forbidden when taking both drugs, because use with alcohol increases drug dependence and enhances central inhibition.
2.A high-fat diet will affect the absorption and peak time of dexzopiclone, reducing the effect. Avoid taking it immediately after eating, as the effect of food on zopiclone is weak.
3.For older patients with difficulty falling asleep, the recommended starting dose is 1 mg at bedtimeFor older patients with difficulty maintaining sleep, the recommended dose is 2 mg at bedtime. Increase the dose if necessary.
4.Common adverse reactions include dry mouth, dizziness and abnormal taste. It needs to be noted that it will affect a person's ability to react to a certain extent. Not recommended for drivers or people working at height.
5.Long-term application can create dependencies. If you are not suffering from chronic insomnia, it is not recommended to use it for more than 4 weeks.
6. Prohibited groups include this product and itPeople with ingredient allergies, patients with respiratory insufficiency and decompensation, patients with myasthenia gravis, severe sleep apnea syndromePatient.
In summary, dexzopiclone has advantages over zopiclone in terms of receptor affinity, drug effect display speed, common dose, adverse reactions, safety, etc., and the elderly can choose zopiclone considering the duration of the drug. Therefore,When using it, the choice should be made according to the individual situation and the doctor's advice