This article is from "Nankai Sun Pharmacist", which is used for medical science popularization for reference. Compound Danshen Dripping Pill and Compound Danshen Tablets are commonly used Chinese patent medicines in clinical practice, their main ingredients are Danshen, Panax notoginseng and borneol, which have the effect of invigorating blood and removing blood stasis, regulating qi and relieving pain, and are mainly used in clinical practice for chest paralysis caused by congestion and obstruction, symptoms of chest tightness, stabbing pain in the precordial area, coronary heart disease angina patients can also take compound Danshen Dripping Pills or compound Danshen tablets when the above symptoms occur, but they must be used after Chinese medicine dialectic, and these two drugs cannot be used alone** Coronary heart disease can be used as a long-term combination drug on the basis of standardization ** for patients with coronary heart pain and angina.
Compound Danshen Dripping Pills and Compound Danshen Tablets are similar in terms of main ingredients, functional indications, indications, etc., what are the differences between them?Today, Pharmacist Sun will explain them to you one by one:
1.Dosage form: Compound Danshen Dripping Pill is a drop pill, this dosage form has the characteristics of rapid dissolution and release, rapid onset, very suitable for sublingual administration, when sublingual administration, the drug is directly absorbed into the blood through the sublingual mucosa, avoiding the first-pass effect of the liver and the degradation of gastrointestinal digestive juices, improving the utilization rate of the drug, which is conducive to the rapid relief of the condition of emergency patients, and is suitable for first aid when coronary heart disease angina occurs.
2.The main active ingredients of Danshen are water-soluble tanshenin and fat-soluble tanshione, which can dilate coronary arteries, increase coronary blood flow, increase myocardial blood supply and oxygen supply, protect ischemic cardiomyocytes, and can scavenge oxygen radicals, inhibit lipid peroxidation, regulate blood lipid profile, inhibit platelet aggregation, prevent the occurrence and development of atherosclerosis, and improve microcirculation. The active ingredients of Panax notoginseng are notoginseng saponins and flavonoids, Panax notoginseng saponins can inhibit platelet aggregation, anticoagulant, anti-inflammatory, prevent the occurrence and development of atherosclerosis, and can dilate peripheral arterioles and reduce blood pressure, flavonoids can regulate blood lipids, borneol is an adjuvant medicine, which can promote the active ingredients of salvia and notoginseng to enter tissues and organs, and has the effect of dilating coronary arteries and analgesic effect. The difference between the two drugs is that the content of tanshenin in compound Danshen dripping pills is higher, and the content of tanshinone is very small, and the content of tanshinone in compound danshen tablets is higher, and the content of tanshenin is only half of that of compound danshen dripping pills, and the pharmacological activity of danshenin on the cardiovascular and cerebrovascular system is stronger.
3.Indications: Compound Danshen Dripping Pill is a drop pill, suitable for sublingual administration, rapid absorption, 3 minutes can take effect, can be used for the first aid of coronary heart disease angina, while compound Danshen tablets can only take effect at least 30 minutes after oral administration, not suitable for the first aid of coronary heart disease angina. In addition, clinical trials have shown that Compound Danshen Dripping Pill can delay the occurrence and development of diabetic macrovascular complications, reduce the excretion of urine protein, and can be used to prevent and treat diabetic complications, while Compound Danshen Tablets lack clinical trial support.
4.Adverse reactions: The dosage of borneol in compound Danshen tablets is large, which is easy to cause gastrointestinal reactions such as nausea, vomiting, abdominal distention, abdominal pain, diarrhea, and abdominal discomfort. In addition, the content of compound Danshen dripping pills is high, and Danshensu has a strong antiplatelet effect, which is easy to cause bleeding, and when combined with aspirin, clopyrrolidine and other drugs, attention should be paid to monitoring the coagulation indicators.
In short, compound Danshen Dripping Pill and Compound Danshen Tablets are commonly used in clinical practice to invigorate blood and dissolve stasis Chinese patent medicines, the main ingredients are Danshen, Panax notoginseng and borneol, compound Danshen Dripping Pill has high danshenin content, stronger pharmacological activity on the cardiovascular and cerebrovascular system, and can be taken sublingually, used for coronary heart disease angina first aid, can also be used to prevent and treat diabetic complications, its amount of borneol is small, the incidence of gastrointestinal reactions is low, but attention should be paid to adverse reactions such as bleeding.