Human facial experiments have confirmed that stretchable electronic SEFM can increase water content by 20%.
Transdermal drug delivery is an effective method. Compared to oral and injectable administration, the transdermal route can avoid absorption and metabolism in the gastrointestinal tract and reduce pain, thereby improving patient compliance. However, only a small amount of drug can be penetrated by passive diffusion**, and it is difficult to maintain an effective level of drug delivery. Su Yewang, a researcher at the Institute of Mechanics of the Chinese Academy of Sciences, designed and prepared a stretchable electron for electroporation, which can promote the effect of 3-4 times the amount of drug introduction, and has the characteristics of reusability, stable washing, low cost and portability.
Stretchable Electron** (SEFM) serves as a facial health care platform (Figure 1) with electrodes for electroporation drug introduction prepared on silica gel** to facilitate transdermal drug delivery.
The key designs and technologies to be overcome in this work include: the introduction of silicone oil materials to enhance the adhesion and deformation stability of conductive ink electrodes on the silica gel surface;The material is ground to reduce the diameter of the aggregate and increase the conductivity of the ink electrodeGraphene material doping to form multiple conductive channels and increase the conductivity of the ink electrode;Serpentine mesh structure design to maintain the electrical stability of conductive ink when it is greatly deformed;Carbon black is doped with high-temperature vulcanized silica gel to achieve conductive bonding and encapsulation.
In this study, the mechanical, electrical properties, and effectiveness of conductive bonding and encapsulation of SEFM were verified by finite element method and experiments, and the effect of SEFM on accelerating the introduction of sodium hyaluronate, aloe vera powder, oat glucan and D-panthenol by 3-4 times was demonstrated through animal experiments, and the introduction depth was increased.
This achievement not only has important academic significance for basic research, but also has a promising prospect for industrial application. The research work was supported by the National Natural Science Commission of China and the Chinese Academy of Sciences.
a. Schematic diagram of the use of SEFM;B. Exterior view of SEFM;C. Internal view of SEFM;d. Controller, including control area and connection point (CPS);e. Pulse waveform, square wave pulse, 60 V, pulse width 200 s;F. Schematic diagram of the drug delivery mechanism of SEFM by electroporation;G. LTR region and LDR region of electroporation drug introduction.