Recently, Hangzhou Meiliu Biotechnology Co., Ltd. has successively completed the "trial production" of 5 tons of 16 kda and 120 kda multiple human type III collagen cans, relying on the Pichia pastoris engineering strain to achieve the target collagen secretion and expression of 12 16 g L. On the basis of remodeling the cell wall of Pichia pastoris, the company practiced the "self-evolution" of multiple secreted signal peptides and the "coupling optimization" of signal peptides and collagen codons through machine learning strategies with the surface charge of the N-terminal domain of collagen as the main parameter, and finally achieved the increase in the secretion and expression of the target collagen in Pichia pastoris, which was 4 9 times that of the starting engineering strainAchieve a selling price of only 10,000 yuan per kilogram(The current market price is 80,000 kg). According to process calculations, the market sales of human-derived type III collagen produced by the company are expected to further decline sharply in the future, boosting Chinese ingredients to go abroad. In addition to the mass-produced human-derived type III collagen, the second-generation "super-functional human-like collagen" developed by the company has completed the pilot test and will carry out animal experiments in the near future, and it is believed that it will enter the mass production stage soon.
Meiliu Biotech is a synthetic biology platform company focusing on the development and mass production capabilities, and the team is composed of top scientific research talents from Zhejiang University and has rich entrepreneurial experience. Adhering to the spirit of scientific and technological innovation, the company is committed to the development and large-scale production capacity of biological products. At present, it has successfully synthesized more than 50 diversified products, covering five major fields, including consumption, materials, medicine, agriculture and industry. Not only that, the company has also developed more than several product series, covering medical beauty and skin care, food and beverage, biomedicine, basic materials, feed, agrochemicals, alternative proteins, pet food and other fields. The company's goal is to create a better life for people and contribute to social development through innovative technology.