JAG2 (jagged-2) is an important member of the NOTCH signaling pathway and plays a key role in cell development, proliferation, and differentiation. JAG2 is a transmembrane protein whose exon moiety is responsible for binding to the Notch receptor, while the intracellular moiety is involved in the regulation of signaling. JAg2 recombinant protein is a product of transcribing JG2 gene into protein through genetic engineering technology, which has important biological functions.
Catalog No. PA1000-7831
The basic information of the JAG2 recombinant protein includes a molecular weight of about 120 kDa, and its structure is characterized by multiple EGF-like domains and Notch binding regions at the N-terminus, and a transmembrane domain and peptide at the C-terminus. The binding between JAG2 and Notch receptors triggers the activation of the Notch signaling pathway, which in turn affects the fate of the cell. During development, JAG2 plays an important role in the development of organs and tissues, such as the heart, blood vessels, nervous system, etc.
JAG2 recombinant protein plays an important role in biological functions such as cell signaling, proliferation, and differentiation. On the one hand, JAG2 is able to bind specifically to the Notch receptor, activate signaling pathways, and regulate cell proliferation and differentiation. On the other hand, JAG2 is also involved in cell-cell interactions, such as cell adhesion and migration. In addition, JAG2 recombinant protein can also affect the growth and metastasis of cells, which has a potential effect.
In addition to its role in normal physiological processes, JAG2 recombinant protein also has important applications in the field of diseases. Studies have shown that JAG2 plays an important role in pathological processes such as cancer, cardiovascular disease, and neurological diseases, so JAG2 recombinant protein can be used as a potential target. At present, there have been many studies exploring the application value of JAG2 recombinant protein in cancer and other diseases, and some preliminary results have been obtained.
In conclusion, JAg2 recombinant protein, as a key member of the NOTCH signaling pathway, plays an important role in biological processes such as cell development, proliferation and differentiation. Its basic information and biological functions have been widely studied and applied, providing a new direction for related diseases. With the in-depth understanding of the mechanism of action of JAG2 recombinant protein, it is believed that it will bring new breakthroughs to the development of the biomedical field in the future.