Abstract Flunarizine is a calcium channel blocker, which is widely used for dizziness, vertigo and other symptoms. This article will introduce flunarizine in detail from the aspects of pharmacological effects, indications, dosage and usage, adverse reactions, contraindications and precautions, in order to provide reference for clinicians and patients.
1. Pharmacological effects.
Flunarizine is a calcium channel blocker, and its main pharmacological effects are as follows:
1.Calcium channel blockade: flunarizine can prevent calcium ions from entering the cell, thereby reducing intracellular calcium overload, and has a long-lasting inhibitory effect on persistent vasospasm caused by vasoconstrictive substances, especially on the basilar artery and internal carotid artery.
2.Vestibular inhibition: flunarizine can increase cochlear arteriolar blood flow and improve vestibular circulation, thus having an antivertigo effect.
3.Antiepileptic effect: Flunarizine can block the pathological calcium overload of nerve cells and prevent paroxysmal depolarization, cell discharge, thereby avoiding seizures.
4.Other effects: Flunarizine also has sedative, antidepressant and other effects, which may be related to its regulation of neurotransmitter levels.
2. Indications
Flunarizine is mainly used for the following conditions:
1.Cerebral blood supply insufficiency: such as transient ischemic attack, cerebral infarction, etc.
2.Vertebral artery ischemia: dizziness and vertigo caused by carotid artery disease, cervical spondylosis, etc.
3.Vestibular dysfunction: such as Meniere's disease, vestibular neuritis, etc.
4.Increased intracranial pressure: such as brain tumors, hydrocephalus, etc.
5.Others: such as migraine prevention, tinnitus, dizziness, etc.
3. Dosage and usage
The dosage and usage of flunarizine are as follows:
1.*Oral, 5-10mg each time, 1 time daily, after meals.
2.Elderly: Oral, 5 mg each time, 1 time daily, after meals.
3.Children: Take orally, 1-2 mg kg each time, once a day, after meals.
The course of treatment is generally 2-4 weeks, and can be extended according to the condition. During use, the patient's symptoms and adverse reactions should be closely monitored, and the ** regimen should be adjusted in time.
4. Adverse reactions.
Common adverse reactions of flunarizine are:
1.Sedative: Some patients may experience drowsiness, fatigue, dizziness, etc.
2.Gastrointestinal reactions: such as nausea, vomiting, dry mouth, etc.
3.Cardiovascular system: such as palpitations, hypotension, etc.
4.Others: such as headache, **allergic reaction, etc.
Serious adverse reactions are rare, and if serious adverse reactions occur, the drug should be stopped immediately and medical attention should be sought immediately.
5. Contraindications.
Flunarizine is contraindicated in the following situations:
1.Those who are allergic to flunarizine.
2.Patients with severe heart block.
3.Patients with severe hepatic dysfunction.
4.Patients with severe renal dysfunction.
5.Pregnant and lactating women.
6. Precautions.
1.When using flunarizine** for dizziness, it should be used reasonably according to the specific condition of the patient, weighing the pros and cons.
2.Patients should avoid activities that require a high degree of concentration, such as driving and working at height, while taking the drug.
3.Patients should have regular blood pressure, heart rate, liver and kidney function tests during the medication.
4.If there is an adverse reaction, please seek medical attention in time and adjust the ** plan.
In conclusion, flunarizine, as a calcium channel blocker, has significant efficacy in dizziness, vertigo and other symptoms. However, in the process of use, rational medication should be used according to the specific condition of the patient, adverse reactions should be closely monitored, and the ** regimen should be adjusted in time. If there are serious adverse reactions, the drug should be stopped immediately and medical attention should be studied.