Most recently, Department of Chemistry, Sun Yat-sen University.
Peng's research group was published in the journal Science.
A photocatalytic-based method for intramolecular free radical sampling.
Inert alkane can be converted.
Realize the "100 steps through the poplar" of "precision guidance".
Why such a breakthrough?
What's so remarkable about this study?
More information will be brought to you today.
Breakthroughs.
Carbon-hydrogen (C-H) bond is an important building block and an important class of organic compounds. If the activation of hydrocarbon bonds can be selectively carried out at specific sites, not only can the excess waste in the synthesis be greatly reduced, but also the high value-added utilization of high value-added products with alkanes as the main raw material can be realized. For a long time, this problem has been quite challenging in the field of organic synthesis and has been called the "holy grail".
Hu Peng's research group from the Department of Chemistry of Tsinghua University said on February 2 that the photocatalytic technology was used to complete the "100 steps of precision guidance" at the inert conversion level of carbon-hydrogen bonds. This method has the characteristics of simple operation and environmental friendliness, which can greatly reduce the time and cost in the synthesis process, not only obtain more high value-added compounds, but also realize efficient and precise structural modification of small molecules with physiological functions, thereby accelerating the development of new drugs. The findings were published in Science, and all three scholars are Ph.D. students at Sun Yat-sen University.
The findings of Hu Peng et al. were published in Science
Tackling the problem. How to effectively regulate its catalytic activity has always been a difficult problem in this field. Whereas, in linear alkyl hydrocarbons, the chemical structure of each hydrocarbon bond is very similar and all are relatively inert. Less reactive reactants cannot activate alkanes, while faster reactants can "wake up" all the carbon-hydrogen bonds at the same time.
Hu Peng said: "At present, there are still great challenges in the directional modification of inert alkane compounds, and only a small number of catalytic materials based on *** have been developed. ”
Therefore, how to synthesize with high efficiency and high selectivity has important scientific significance and application value. Due to its poor selectivity in the catalytic system, it is easy to generate one or more by-products, causing a lot of waste and pollution, which is of great significance for sustainable development. In the production process, in order to obtain the target product, it is often necessary to carry out multiple steps of synthesis under the influence of a more intense catalyst. The process is not only a waste of resources, but also consumes energy and is not very energy efficient overall, putting enormous pressure on the ecosystem.
Wang Miao, a man, said that their research team used a variety of substances, and in daily life, the largest and most abundant is oil, which is composed mainly of simple alkanes. The research team uses selective boronation of hydrocarbon-hydrogen bonds to convert petroleum into high value-added chemicals, not just fuels.
Group photo of Hu Peng and others.
In the previous work, the research group activated the carbon-hydrogen bond by a special site in the alkane, and then continued the catalysis, and the results showed that the selectivity of the method was not ideal.
After a large number of experiments, our group has discovered a new catalytic pathway, and its mechanism studies have shown that there is a reversible hydrogen bond transfer (HAT) in this reaction. Firstly, the carbon-hydrogen bonds are activated unrestricted to form various types of active species, and then the steric hindrance of these active species is used to achieve specific recognition and catalysis of some active species, so that the inactive species are reduced to alkane compounds. Through the implementation of this project, the difficulty of functionalization of C-H bonds will be greatly reduced.
This project focuses on carbon-hydrogen bonding, and the carbon-hydrogen bond-centered boronization reaction is the center.
Using boronoids as an important organic synthesis primitive, we can also use it to construct new molecules with diverse structures and functions for various types of catalytic systems. Hu Peng said.
Fe is one of the most abundant in nature, which is inexpensive, extensive, and diverse. Solar energy is nature's most ubiquitous form of energy** and is easy to use in the lab.
The reaction conditions of this reaction are relatively simple, can be mass-produced in the laboratory, and has strong adaptability to the substrate of the reaction, which can achieve compatibility with functional groups such as alkenes, alkynes, chlorine, bromine, esters and other functional groups that are easy to follow-up reactions. Applicant Huang Yahao said.
Hu Peng's research team is based on simple and efficient cheap catalysts, and selectively cuts inert chemical bonds to achieve the goal of "molecular gardening" in the green economy. At the same time, the research group has also successfully carried out a series of activation of carbon-hydrogen bonds and carbon-carbon double bonds, and for the first time, a series of chemical transformations such as plastic degradation and alcohol bond breaking have been realized.
Professor Hu Peng said that on this basis, we will conduct in-depth research on the system to achieve a variety of challenging chemical synthesis, construct a convenient molecular shearing method, and complete the ideal of "molecular garden".
This project is jointly funded by the Pearl River Outstanding Youth of Guangdong Province, the Key Laboratory of "Functional and Molecular Engineering" of Guangdong Provincial Universities, the Institute of Biochemical Engineering and Biotechnology of Sun Yat-sen University, and the Lane Institute of Functional Materials.
Hu Peng. He is currently the deputy director of the Institute of Chemical Engineering of Guangdong Normal University. Outstanding young and middle-aged experts in Zhujiang, outstanding young and middle-aged experts in the "100 Talents Program" of Guangdong Normal University. The main research contents of this project are: the study of chemical bond breaking and formation mechanism in metal oxide-based catalytic systems based on metal oxides, and their application in green and environmentally friendly organic synthesis; The photothermal catalytic system is a new and efficient synthesis method. A new method for the preparation of heterogeneous catalytic materials was introduced. 2. Activation and utilization of organic small molecules.
Source: Propaganda Department of the Youth League Committee, Department of Chemistry, Sun Yat-sen University.
Author: Zhu Jiahao.
Format: Zhang Junqi.
No. 1: Qiu Qingmeng.
Preliminary review: Li Jianping.
Reviewer: Sun Yaobin.
Reviewer: Huang Yan.