Gamma oryzanol is not a vitamin, but a mixture of natural oils, widely found in the epidermis of grains such as brown rice, corn, wheat, wheat bran, etc., the drug gamma oryzanol is extracted from rice bran oil and germ oil, the main components are phytoenol and ferulate, which has antioxidant activity, and can regulate autonomic nerve dysfunction and endocrine balance disorders, improve tension and anxiety, stabilize mood, and is suitable for sedation and sleep aid for neurosis, premenstrual tension syndrome and menopausal syndrome, and its role is mainly to regulate, There is no clear sedative-hypnotic effect, and it may be effective for mild insomnia, but almost ineffective for moderate and severe insomnia.
Gamma oryzanol has antioxidant effects, can regulate blood lipids, helps to reduce total cholesterol, LDL cholesterol and triglyceride levels, and increases HDL cholesterol levels, which is suitable for the auxiliary treatment of blood lipid disorders**. Gamma oryzanol has an antioxidant effect, which can inhibit the formation and diffusion of melanin, lighten dark spots, and beautify skin care. Gamma oryzanol is suitable for the adjuvant of arrhythmia and angina pectoris by regulating autonomic nerve dysfunction, reducing myocardial cell excitability, and improving the blood flow of myocardium**. Gamma oryzanol is suitable for the auxiliary treatment of chronic gastritis and peptic ulcer by regulating autonomic nerve dysfunction, reducing vagus nerve excitability and reducing gastric acid secretion. However, most of these off-label uses of gamma oryzanol are based on observational studies with small sample sizes, which are poorly designed, flawed, and have limited reliability, so these uses of gamma oryzanol need to be confirmed by further well-designed clinical trials.
Gamma oryzanol is extracted from natural grain oils, according to the regular dose of short-term use safety and tolerability is good, **usually mild and short-term, generally can be recovered after discontinuation, but long-term or high-dose use of gamma oryzanol is easy to lead to autonomic nerve dysfunction, causing nausea, vomiting, bloating, diarrhea, slow digestion, stomach discomfort, constipation and other digestive systems*** and increased blood pressure, rapid heartbeat, chest tightness, chest pain and other circulatory system*** Similarly, long-term or high-dose use of gamma oryzanol is easy to lead to endocrine dysfunction, Causes weight gain, breast tenderness and hair loss***
Gamma oryzanol has strong fat solubility, if mixed with oil, it can be better absorbed, if taken on an empty stomach, without oil as a carrier, the absorption rate of gamma oryzanol will be significantly reduced, therefore, it is recommended to take gamma oryzanol during or after meals. In addition, gamma oryzanol has a certain irritation to the gastrointestinal tract, which is easy to cause diarrhea, abdominal pain, nausea, vomiting, stomach discomfort and other gastrointestinal tract *** taken during or after meals, with food as an interval, it can effectively prevent or reduce gastrointestinal reactions, therefore, choose to take gamma oryzanol during or after meals, not only has good efficacy, but also less, killing two birds with one stone, the dosage is 3 times a day, 1-3 tablets each time.
Gamma oryzanol is a drug, not a health care product, should be taken under the guidance of a doctor or pharmacist, long-term or large doses of gamma oryzanol can easily lead to autonomic nerve and endocrine dysfunction, increase the incidence of ***. The course of medication should be determined according to the indications of gamma oryzanol, such as gamma oryzanol for sedation and sleep aid for neurosis, premenstrual syndrome and menopausal syndrome, generally 1-3 months for a course of treatment, ** chronic gastritis, arrhythmia or angina, generally 2-4 weeks for a course of treatment, according to the condition to extend the time of medication, it is not recommended to take gamma oryzanol for a long time, if the symptoms are not relieved after 7 days of medication, you should consult a physician or pharmacist in time.
Diazepam, commonly known as diazepam, belongs to the classical benzodiazepine sedative-hypnotic drugs, acting on benzodiazepine receptors in the central nervous system, with sedative-hypnotic, anti-anxiety, anti-convulsant, anti-epileptic and muscle relaxation effects, suitable for insomnia, anxiety and status epilepticus, can produce similar physiological sleep, shorten the time to fall asleep, reduce the number of night awakenings and early awakenings, prolong the total sleep time, and improve sleep quality. Compared with gamma oryzanol, the hypnotic effect of diazepam is clear and reliable, and it has a good effect on various insomnia, while gamma oryzanol is mainly suitable for insomnia caused by autonomic nerve dysfunction and endocrine dysfunction, and has little effect on moderate and severe insomnia.