Diclofenac sodium is a commonly used antipyretic, analgesic and anti-inflammatory drug in clinical practice, classified as aromatic acid, mainly by inhibiting cyclooxygenase, interfering with the synthesis of prostaglandins, an inflammatory mediator, to achieve the purpose of antipyretic, analgesic, anti-inflammatory and anti-rheumatism, belonging to a strong antipyretic, analgesic and anti-inflammatory drug, its antipyretic, anti-inflammatory, analgesic effect is 2-3 times that of indomethacin, 26-50 times that of aspirin, analgesia does not produce euphoria and dependence at the same time, does not inhibit breathing, and is ineffective against sharp pain caused by direct stimulation of sensory nerve endings, It is especially suitable for persistent inflammatory dull pain, such as headache, migraine, toothache, arthralgia, neuralgia, muscle pain, dysmenorrhea and other mild and moderate pain, rheumatoid arthritis, osteoarthritis, gouty arthritis, ankylosing spondylitis and various non-articular soft tissue pain such as muscle pain, neck and shoulder pain, tenosynovitis, bursitis and post-sports injury pain.
Diclofenac sodium enteric-coated tablets and extended-release tablets are different dosage forms of diclofenac sodium, enteric-coated tablets release drugs in the intestinal collapse, and sustained-release tablets slowly dissolve and release drugs in the gastrointestinal tract, making enteric-coated tablets or sustained-release tablets can help prevent or alleviate gastrointestinal adverse reactions caused by diclofenac sodium. Enteric-coated tablets are usually available in 25 mg tablets and extended-release tablets are usually available in 75 mg tablets. It is recommended to take enteric-coated tablets before meals and sustained-release tablets during meals. Enteric-coated tablets have a faster onset of action, but the action time is short, and they need to be taken multiple times a day, and the onset of sustained-release tablets is slower, but the action time is long, taken once a day, and the medication compliance is good, and the efficacy of enteric-coated tablets and sustained-release tablets is comparable under the same dosage. Compared with enteric-coated tablets, extended-release tablets were better tolerated by the gastrointestinal tract and had a lower incidence of gastrointestinal adverse reactions.
Diclofenac sodium *** has a high incidence rate, statistics can reach 20%, about 2% of patients are discontinued due to intolerance, common nausea, vomiting, stomach distention, abdominal pain, indigestion and loss of appetite and other gastrointestinal reactions, is its most common long-term use can cause gastritis, and even gastrointestinal ulcers and gastrointestinal bleeding. In addition, diclofenac sodium can also be seen mild headache, dizziness, vertigo and other nervous systems*** and cardiovascular systems such as palpitations and increased blood pressure*** For people with ischemic heart disease, long-term use can increase the risk of cardiovascular events such as heart failure and myocardial infarction, and finally, diclofenac sodium can also cause elevated liver aminotransferases, and rashes are common in people with allergies.
In view of the fact that diclofenac sodium can only relieve symptoms, can not improve the prognosis, and there are large safety risks in long-term use, therefore, it is recommended to use the lowest effective dose in the shortest possible time under the premise of controlling symptoms to reduce the risk of occurrence, for mild and moderate pain such as toothache, headache, muscle pain, neuralgia, as well as muscle pain, neck and shoulder pain, tenosynovitis and other non-articular soft tissue pain, continuous medication should not exceed 1 week, for rheumatoid arthritis, osteoarthritis, Gouty arthritis and other osteoarthritis pain, continuous medication should not exceed 4 weeks, try to take it as needed and intermittently, the risk of gastrointestinal tract, liver, kidney, brain, cardiovascular disease should be strictly assessed before medication, and the elderly who are weak and low body weight should be cautious with diclofenac sodium, and continuous medication should not exceed 1 week.
Ibuprofen and diclofenac sodium belong to the same kind of drugs, there are many similarities, there are also some differences, first, in terms of analgesia and speed of action, compared with ibuprofen, diclofenac sodium has a stronger inhibitory effect on prostaglandin synthesis, and its antipyretic, analgesic, anti-inflammatory effects are more than 20 times that of ibuprofen, and oral absorption is rapid and complete, and the onset of action is faster. Second, in terms of medication, ibuprofen should not be used for antipyretic for more than 3 days, for analgesia for no more than 5 days, and diclofenac sodium should not be used continuously for more than 1 week. In terms of the time of taking the drug, it is recommended that ibuprofen and diclofenac sodium be taken with meals, which can prevent or alleviate gastrointestinal reactions, and diclofenac sodium enterosolvent is suitable for taking before meals. In terms of safety, in addition to the gastrointestinal tract, nervous system, cardiovascular system, and liver***, ibuprofen can also cause tinnitus and blurred vision, while diclofenac sodium*** has a higher incidence.