PolyD,L lactide co glycolide disulfide bond polyethylene glycol cyclic peptide

Mondo Health Updated on 2024-02-01

Product name: Poly(D,L-lactide-Co-glycolide)-disulfide bond-polyethylene glycol-cyclic peptide.

Product Name: plga-ss-peg-crgd

Introduction:Poly(D,L-lactide-co-glycolide)-disulfide-polyethylene glycol-cyclic peptide is a new type of biodegradable polymer material with good biocompatibility and degradability. The material can be used in drug delivery, genetics, tissue engineering, and other fields, providing a new solution for the biomedical field. Synthesis method: The synthesis of poly(D,L-lactide-co-glycolide)-disulfide bond-polyethylene glycol-cyclic peptide involves multiple steps. First, copolymers of D, L-lactide and glycolide were synthesized by copolymerization. Then, disulfide bonds are introduced into the polymer chain, making them reactive. Next, polyethylene glycol is linked to cyclic peptides to form polymer nanoparticles. Finally, the product is purified by dialysis, ultrafiltration, lyophilization and other methods. Applications:1Drug delivery: poly(D,L-lactide-co-glycolide)-disulfide-polyethylene glycol-cyclic peptide can be used to prepare drug delivery systems, such as nanomedicines, microspheres, etc. These drug delivery systems can improve the targeting of drugs, reduce toxicity, and thus improve the efficacy. 2.Gene**: The use of poly(D,L-lactide-co-glycolide)-disulfide-polyethylene glycol-cyclic peptide as a gene delivery carrier can protect genes from degradation and improve the transfection efficiency and stability of genes. This material has a broad application prospect in the field of genetics. 3.Tissue engineering: Poly(D,L-lactide-co-glycolide)-disulfide-polyethylene glycol-cyclic peptide can be used as scaffold materials for tissue engineering to provide a good growth environment for cells. This material has good biocompatibility and degradability, which can promote the proliferation and differentiation of cells, and provide strong support for the development of the field of tissue engineering.

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Edited by Qi Yuehao, January 9, 2024.

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