2-Nitrobenzaldehyde oxime (CAS: 6635-41-2) with the chemical formula C7H6N2O3 and a molecular weight of 16613g/mol。This compound is an organic compound with a unique structure and a variety of applications. Its appearance is white to light yellow crystal, the melting point is 105-107 degrees Celsius, and it can be soluble in organic solvents such as ethanol and ether after melting.
2-Nitrobenzaldehyde oxime has certain chemical stability and can be stored for a long time at room temperature. Chemically, it can be reduced to 2-nitrobenzaldehyde, and nucleophilic substitution reactions can also occur to generate different derivatives. In addition, it has certain optical activity and can be used in the synthesis of chiral compounds.
At present, the synthesis route of 2-nitrobenzaldehyde oxime mainly includes the reaction of benzaldehyde with sodium nitrate to prepare nitrobenzaldehyde, and then hydrogen reduction to obtain 2-nitrobenzaldehyde, and finally the synthesis of 2-nitrobenzaldehyde oxime by sodium hydroxide and hydroxylamine reaction. This synthetic route is simple and easy to carry out, and the reaction conditions are mild, making it suitable for industrial production.
There are two main preparation methods of 2-nitrobenzaldehyde oxime, one is obtained by the reduction reaction of nitrobenzaldehyde; The second is prepared by the reaction of 2-nitrobenzaldehyde and hydroxylamine. Among them, the second method is more commonly used and has higher yields and purity.
As an important intermediate in organic synthesis, 2-nitrobenzaldehyde oxime has a wide range of application prospects in medicine, pesticides, dyes and other fields. It can be used to synthesize various amino acids, hormones, alkaloids and other organic compounds, and can also be used as a catalyst or reducing agent.
In recent years, microchannel technology has been widely used in the field of organic synthesis, and its advantages of continuous synthesis have gradually become prominent. For the production of 2-nitrobenzaldehyde oxime, microchannel continuous synthesis has become a research hotspot. Through the microchannel reactor, the precise control of reaction conditions can be realized, the yield can be improved, the waste emission can be reduced, and the production cost can be further reduced. In the future, with the continuous innovation and development of microchannel technology, the production of 2-nitrobenzaldehyde oxime will be more efficient and environmentally friendly.
In summary, 2-nitrobenzaldehyde oxime, as an important intermediate in organic synthesis, has a wide range of application prospects. Through the optimization of synthetic routes and the continuous development of microchannels, the production efficiency and quality can be improved, and the development of related industries can be promoted. In the future, we can further study its application in the field of medicine and pesticides, explore more synthesis methods and reaction conditions, and provide more possibilities for the comprehensive utilization of this compound.