This issue of the Expert Class
expert lecture
Allergies in hairy children,In addition to allergens,
Are there any other triggers?
When I was working with the Animal Hospital Affiliated to the College of Veterinary Medicine of National Taiwan University, I communicated with Professor Huang Huibi and learned about two cases:Case 1:Severe**Allergic Akita dog, after a variety of methods of medicine** have no obvious effect, by chance a pet doctor found that the hairy child was abnormally active in the clinic, thinking that it was caused by mental stress? After inquiring about the pet owner in detail, it was found that they were busy with work and rarely took the furry child out, so that the hairy child's inner pressure caused by disease. Case 2:Mixed-breed dogs who live in urban areas, the physical symptoms are limited under the drug, and later due to the change of the pet owner's work, the hairy child is handed over to the parents who live in the countryside to take care of, and the hairy child runs and plays in the field, and the diet is not taboo, and the symptoms gradually improve.
The above two cases are allergies caused by psychological factors! Today we're going to talk about what isPsychoneuroimmunology
When we come to the hospital with allergies, the doctor may put it down** to being stressed or in a bad mood. This concept has been around since 1948 and has been known since 2009 as "psychoneuroimmunology".
Psychological stressIt encompasses a wide range of stress, which is divided into acute stress and chronic stress. To put it simply, the people, things, places, and things that cause the furry child to feel uncomfortable and want to stay away are all pressures, and the unmet needs for a long time are also a kind of pressure. Stress stimulates the hypothalamus and parathalamic nucleus (PVN), which regulates blood pressure, and the blue nucleus of the central nervous system.
Hypothalamic-pituitary-adrenal (HPA) pathway:The production of catecholamines and corticosteroids in the upper cortex of the kidneys stimulates the rise of IL-4 and IL-13 (which are responsible for inducing the regulation of the production of B cell IgE, and the water in the glass of allergies increases), and inhibits the expression of IL-12 in APC (antigen-presenting cells).
Blue nucleus-brainstem pathway:The production of norepinephrine (which is also produced by the upper renal line) also inhibits the performance of IL-12, and the decline of IL-12 leads to a decrease in interferon-gamma (IFN-, an important factor in Th1) and tumor necrosis factor-alpha (TNF-), which ultimately leads to a deviation towards Th2 allergies (i.e., a hole in the cup of the allergic water cup). Stress also causes an increase in serotonin, an inflammation-inducing precursor that causes swelling and vasodilation, and therefore itching.
Therefore, in clinical practice, there is empirical evidence for both animals and humansPsychological stress is also a factor that triggers allergies。Among them, canine atopic dermatitis (CAD) is particularly obvious, especially for children with little activity due to long-term pressure in the room to produce CAD, as a result of the use of treadmill to relieve pressure and heal without medicine.
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