Article 1992Brain Science**
February 7, 2023day
Science Times
Cell Stem Cell: Suchun Zhang's team uses 3D printing functional human brain tissue
*：bioart
Each type of organ is different in composition and function from the other, and there is currently no one way to control this. And 3D printed brain tissue is a great way to overcome this problem because its composition is completely controllable. Recently, the team of Suchun Zhang, professor of neuroscience and neurology at the University of Wisconsin-Madison and researcher at the Wiseman Center, has achieved 3D printing of functional brain tissue for the first time.
Researchers have developed a novel 3D printing technique and method that allows neurons derived from induced pluripotent stem cells (iPSCs) to form connections between the printed brain tissue and layers, allowing these neurons to begin to function like cells in human brain tissue. This 3D printing brain tissue technology solution is a major advancement in the field of 3D printing of human tissues, which is used to study the molecular mechanisms of brain development, human development, developmental disorders, neurodegenerative diseases, etc. In addition, the protocol can also be used as a drug screening platform or drug testing platform.
Nat Rev Neurosci Express: Causality in Neuroscience
*: Chichi Club.
One of the fundamental goals of neuroscience research is to explain the causal structure of the brain. Causal information can help explain brain function and understand the consequences of behavior. A recent review article elaborates on "causality" and "mechanism" from the perspectives of neuroscience and philosophy of science, describes the standard use of these concepts in neuroscience, and makes suggestions for future work.
ACS nano: a panel of high-performance plasma biomarkers and femtomolar label-free biosensing systems for screening Alzheimer's disease
*: BioMed Technologies.
Recently, Professor Zhang Yan's research group from the School of Life Sciences of Peking University used an ultrasensitive graphene field-effect transistor (GFET) sensor to determine the content of Alzheimer's disease (AD) biomarkers amyloid A40, A 42, phosphorylated P-tau181, P-tau217 and neurofilament light chain protein (NFL) in human plasma in a multicenter clinical cohort.
In this study, a machine learning algorithm was used to analyze the combination of these plasma biomarkers, and a "composite-info" biomarker panel was constructed, which significantly improved the staging performance of AD progression. On the receiver operating characteristic curve (ROC), the area under the curve (AUC) of the combination is greater than 094。In addition, the study demonstrated superiority in individual-based staging assessment compared to the Mini-Mental State Inventory (MMSE), the Montreal Cognitive Assessment (MOCA) and Magnetic Resonance Imaging (MRI), providing a rapid detection and diagnostic system for early screening of AD.
IEEE Sub-Journal: Improving the Performance of Motor Imaging Brain-Computer Interfaces in Underperforming Subjects Using a Mixed Imaging Paradigm Combining Motor and Somatosensory Activities
*: BME** Engineering Branch.
The Brain-Computer Interface Based on Motor Imaging (MI-BCI) can be intuitively mapped based on interfaces and control commands to efficiently control external devices. However, compared to other BCI paradigms, Mi-BCI exhibits lower transmission rates and reliability in identifying participants' intent, and this phenomenon is particularly prominent among users with poor performance. Recently, a research team from Hanyang University in South Korea used a hybrid imaging paradigm that combines motor and somatosensory activities to improve the classification performance of brain-computer interface based on motor imagination of underperforming subjects, and found that the new paradigm of mixed imagination can provide higher attention and discrimination for underperforming subjects, and enhance event-related desynchronization mode, which provides a new idea for improving the performance of motor imaging brain-computer interface.
European Radiology: a novel radiomics model for post-stroke epilepsy
*: New frontiers in Metz Neuro.
Post-stroke epilepsy (PSE) is a common sequelae of stroke, clinically defined as seizures more than 7 days after stroke, affecting 31-9.5% of stroke patients. Recently, a study examined the role and value of radiomics in ICH-related PSE, established a model combining radiomics and clinical practice, and evaluated the differences and advantages between its performance and clinical models alone. Studies have shown that the combined radiomics-clinical model is able to better **ICH-related PSE compared to clinical models. This can assist clinicians to better assess the risk of developing PSE in patients after the first ICH and facilitate early diagnosis and development of PSE.
Current Psychiatry: What exactly is Delirium Mania that can be fatal?
*: Yimaitong Psychiatry.
Delirious mania is a clinical syndrome characterized by sudden onset of severe hyperactivity, psychotic symptoms, catatia, and intermittent episodes of confusion. Over the past two decades, there have been increasing reports of delirium mania, but clinical awareness and understanding of the syndrome remains markedly inadequate. A recent review introduced the history, clinical manifestations, and prognosis of delirium mania by reviewing relevant literature and case reports.
Psych Journal: How to turn the aggression of the "bear child" into creativity? New revelations from creative thinking training
*: Wiley.
Historical experience shows that many of the children who grow up to make great creative contributions may not be honest and obedient "good children", but have some characteristics of "bear children", most of them are flexible, energetic, exploratory, and unconventional. Recently, the team of Professor Luo Jin, Beijing Key Laboratory of Learning and Cognition, School of Psychology, Capital Normal University, proposed an intervention strategy for creative thinking training, and proved that this intervention strategy can transform students' aggression into creativity and achieve the educational effect of "turning harm into treasure".
8，health communication：How to reduce body anxiety on social **?
*: Lei Li and the students.
A study from Washington State University has shown that a few words of praise for the body can help counteract the negative effects of the personification of female fitness figures. While fitness influencers say they want to inspire good physical health, research has found that their posts on social tend to inspire negative mental health, especially among younger women. The negative effects of an idealized wall may be offset by something as simple as appreciating the body, such as "Love your body and see what it can do." ”
Reviewer: Simon