Recently, the team of Professor Hu Junbo and Professor Wang Guihua of Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology and the team of Professor Xu Chuan of University of Electronic Science and Technology of China revealed the molecular mechanism of colon cancer metastasis through RNA sequencing, protein profiling analysis, in vivo and in vitro experiments and other experiments, and proposed that small molecule polypeptides can effectively inhibit the metastasis of colon cancer cells, providing theoretical support for targeted intervention of colon cancer, especially metastatic colon cancer. The results were recently published in the Proceedings of the National Academy of Sciences.
Colon cancer is one of the major malignant tumors that threaten human health, and its incidence and mortality are ranked third and fourth respectively, and are increasing year by year. The prognosis of advanced colon cancer is poor, and metastasis is the main cause of its failure and death. At present, the key molecules in colon cancer metastasis can not only provide the metastatic potential of the primary tumor, but also provide a basis for the development of targeted drugs.
This study found that the histone methyltransferase NSD2 activated RAC1 signaling by catalyzing the methylation of the guanylate exchange factor Tiam1 protein and promoted the metastasis of colon cancer. In clinical specimens, high expression of NSD2 and hypermethylation of TiAM1 are associated with poor prognosis of colon cancer. It can be seen that NSD2 and TiAM1 are molecules that play a key role in colon cancer metastasis. In in vitro and in vivo experiments, small molecule peptides targeting NSD2-TiAM1 interaction can effectively inhibit the metastasis of colon cancer cells. Therefore, the development of interventional small molecule peptide drugs based on NSD2-Tiam1 signaling is expected to provide new ideas for the targeting** of colon cancer. (Correspondent Chang Yu, Song Da, Yangtze River ** reporter Wang Kaining).
Editor: Yu Lina].
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