The official name of acne and pimples is acne, which used to occur mostly in adolescents, but in recent years, acne has continued to adulthood, or the number of people who have started acne in adulthood has increased, becoming one of the common diseases that plague people. Not only does acne cause redness, but it can also leave scars after healing. As a first-line drug for acne**, do isotretinoin softgels have a role to play for this?
Acne is actually a chronic inflammation of the sebaceous glands of the hair follicles, which tends to occur in the face, chest and back and other areas where the sebaceous glands are developed, and the skin lesions can manifest as acne, inflammatory papules, pustules, nodules, and cysts. Acne does not necessarily leave scars, but the severity of the lesions affects the impact on ** after healing, generally speaking, the more severe the acne onset and the higher the degree of inflammatory response, the greater the likelihood of acne scarring. Post-acne scars are mainly depressed scars, commonly known as "acne pits", and their important clinical manifestations are lifelong, which not only obviously affect the patient's appearance, but also seriously affect the patient's psychology.
Therefore, acne is not a simple skin problem in most people's cognition, but a disfiguring disease that may cause serious damage to the appearance, and it is necessary to control the skin lesions through timely and standardized ** to avoid acne scars.
Isotretinoin softgels are natural metabolites of vitamin A, which have a strong effect on inhibiting the synthesis of sebaceous lipids, and can also affect the four main pathogenesis of acne at the same time. The pathogenesis of acne is still unclear, but it is believed to be mainly related to increased secretion of sebaceous glands, abnormal keratinization of the sebaceous ducts of hair follicles, and overgrowth of microorganisms such as P. acnes that induce and aggravate inflammatory immune responses. Oral isotretinoin softgels have the anti-inflammatory effect of inhibiting sebaceous lipid synthesis, improving sebaceous ductal hyperkeratinization, reducing the reproduction of Propionibacterium acnes by improving the microenvironment, and participating in the regulation of acne-related immune factors. In addition, isotretinoin softgels also have the effect of preventing acne scarring.
The effectiveness of oral isotretinoin soft capsules** has been studied in a large number of clinical studies, but the acne on the face has been around for a long time, whether to take oral isotretinoin soft capsules** or not depends on the severity of the skin lesions. In general, oral isotretinoin softgels are suitable for the following:
First-line drug for nodular cystic severe acne;
Alternatives to moderate or moderate to severe acne that do not work well with other methods**;
Acne patients with scarring or scarring tendencies should use it as soon as possible;
Frequent acne is ineffective;
acne with severe seborrhea;
mild to moderate acne but patients who need rapid results;
Acne variants, such as acne fulminans and acne polymeris, can be applied after the inflammatory response is controlled with antimicrobial drugs and glucocorticoids.
Symptomatic**, under the guidance of a doctor, oral isotretinoin soft capsules**Acne generally takes effect in 3 4 weeks, and the course of medication is mainly based on the control of acne lesions, usually not less than 16 weeks, and after the acne lesions are controlled, the dose can be appropriately reduced and continued to be taken for 2 3 months or longer to consolidate the results achieved in the early stage.
As mentioned earlier, acne scarring correlates with the severity of the inflammatory response, and the more severe the inflammatory response and the deeper the lesions, the greater the likelihood of scarring. For example, skin lesions such as nodules and cysts with a high degree of inflammation can destroy the structure of hair follicles, allowing sebum and bacteria to enter the dermis, inducing local immune damage and fibrous hyperplasia, leading to acne scarring; Focal purulent lesionsIn the healing process, the defect after the discharge of pus and necrotic tissue cannot be repaired by normal tissue, and a depressed scar is formed.
Isotretinoin softgels have no effect on acne scars that have already formed, but they do have a role in preventing scarring, which may be related to their control and reduction of acne-related inflammatory responses. Therefore, people with obvious inflammatory manifestations or scarring of acne are recommended to undergo ** as soon as possible to avoid acne scarring.
What about pre-existing acne scars? Active acne lesions are the main cause of scarring, if acne still occurs frequently, it is recommended to first accept the standard acne**, after the skin lesions are fully controlled, and then according to the nature of the scar, color and other problems that exist at the same time, under the guidance of professionals, flexible selection of surgery, laser and other ** methods to fade the scar and reduce the impact of acne on appearance.
Acne is not a simple problem, only by changing the care method, choosing the corresponding functional products, etc., most of them can not achieve satisfactory results, but may be aggravated by improper care or products, and eventually lead to the appearance of acne scars. If you have acne problems, you should actively seek medical attention and accept the norms** to control the skin lesions as soon as possible, so as to prevent the appearance of acne scars and avoid greater damage to your appearance.
References:Chinese Acne ** Guidelines (2019 Revised Edition).
Song Yang, Li Shanshan, Zhou Junfeng. Classification and method of depressed scars after acne[J].Chinese Medical Abstracts:Science,2015(1):7doi:cnki:sun:zyxw.0.2015-01-013.