Grandpa Li, male, 70 years oldHave had high blood pressure for 10 years。Over the years, he has been taking his medication on time, living a regular life, and trying not to let high blood pressure affect his life. However, in recent times, the increase in blood pressure has been somewhat uncontrolled, and Grandpa Li himself has increased the daily dose of amlodipine,Change from 10 mg per day to 20 mg per day.
Three days ago, Grandpa Li suddenly feltDizziness, nausea, mental stateIt's not as good as it used to be. He thought it was just due to his age, but the symptoms became more and more serious, and even affected his daily life. Grandpa Li thought that it might be caused by taking too much medicine, so he decided to stop taking amlodipine immediately. But gradually, heDizziness, headacheNot only did the symptoms not get better, but they were worse than before. Chest tightness, shortness of breathThe situation has also emerged one after another.
In desperation, Grandpa Li had no choice but to go to the hospital for an examination. Brain CT shows substantial rectangular or oval isodensities within the skullThe surrounding structure is blurred。The doctor told him that he had suffered a cerebral infarction. This news was like a bolt from the blue for Grandpa Li, he couldn't figure it out, he just had high blood pressure, how could he still have a cerebral infarction?
After inquiring about Grandpa Li's medication in detail, the doctor told him that an overdose of amlodipine may have caused his cerebral infarction. Hydrolodipine is a commonly used antihypertensive drug, but an overdose may harden the cerebral arteries and increase the risk of cerebral infarction.
And the reason for his dizziness was that his blood pressure had risen to a very dangerous level due to self-discontinuation of the medication. Amlodipine works to help control blood pressure, which can be easily ** and may even be higher than before if the drug is stopped abruptly. This condition is very harmful to the body and can easily cause cardiovascular and cerebrovascular diseases.
Hearing this conclusion, Grandpa Li felt very frustrated. After returning home, Grandpa Li took the medicine strictly according to the doctor's instructions, neither casually increasing the dosage of the medicine, nor stopping the medicine on his own. After a period of **and** training, Grandpa Li's physical condition gradually improved, and he was pleasantly surprised to find that his hypertension symptoms had been significantly reduced.
Dizziness and headaches are becoming less and less common, and blood pressure is kept at a normal level, with systolic blood pressure below 140 mmHg.
Through this experience, Grandpa Li understood that when taking medication to control hypertension for a long time, we should pay attention to the adverse effects of overdose and self-discontinuation of medication on the body, and strictly follow the doctor's instructions to avoid mistakes.
At the same time, he also reminded his family members to pay attention to their physical condition, conduct regular check-ups and assessments, and detect and control chronic diseases such as hypertension in time.
If you find any abnormalities, you should seek medical attention in time and inform yourself in detail about your medication. When taking medication, we should strictly follow the doctor's advice and take the medicine according to the doctor's instructions. However, Grandpa Li is still very puzzled, what is the reason for amlodipine to cause cerebral infarction?
Inhibits the entry of calcium ions into myocardial and vascular smooth muscle cellsIt is the key for amlodipine to exert its antihypertensive and angina relief effects. The entry of extracellular calcium ions into the cell stimulates contraction of vascular smooth muscle and myocardium, and amlodipine selectively inhibits this process.
In the cardiovascular system, calcium ions play an important role. The contraction of cardiomyocytes depends on the concentration of calcium ions within the cell, and the contraction of vascular smooth muscle is also regulated by calcium ions. Therefore, the contractility of the myocardium and the reduction of the tone of the vascular smooth muscle can effectively achieve the effect of lowering blood pressure. In addition, in the case of angina, the main effect of amlodipine is its effective inhibition of coronary spasm.
It is important to note that amlodipine is generally taken after taking itMaximum efficacy is achieved in 6-12 weeksSlow onset of action。This is related to its slower absorption in the human body and its slower rate of receptor binding and dissociation. But it also means that it is able to depressurize smoothlyOnce-daily medication can achieve a 24-hour antihypertensive effect
Although amlodipine is a common antihypertensive drug, it is not something that can be taken casually, and there are two aspects that should be paid special attention to when using hydrolodipine** hypertension.
Self-discontinuation or dose changes are two of the most important aspects that patients need to be aware of when taking hydrolodipine, a blood pressure medication. Because not taking the medication in the prescribed way may cause blood pressure fluctuations and may even aggravate the condition, we must pay attention to it and avoid making mistakes.
1 You can't stop the drug on your own
First, hydrolodipine is a prescription drug that works to help control blood pressure. If you stop taking the medication suddenly, your blood pressure may be ** and may even be higher than it was before taking the medication. This condition can lead to a range of health problems such as heart attacks, strokes, etc. Therefore, if you need to stop taking hydrolodipine, you should consult your doctor first and gradually reduce the dose under your doctor's guidance.
2.The dosage cannot be changed at will
Secondly, changing the dosage also needs to be handled with caution. Everyone's physical condition and condition are different, and doctors will choose different types of antihypertensive drugs, dosage, and time to take them according to the specific situation of the patient. If you feel unwell after taking the current dose, you should consult your doctor immediately and not change the dosage yourself. If you need to increase the dose, the doctor will make a decision based on your situation. If you need to reduce the dose, the doctor will also make a decision based on your situation.
In addition to the above two errors,Combination of drugs in patients with hypertension, amlodipine with other drugs needs to be carefully consideredInteraction and potential ***
First of all,Metabolism and excretion of amlodipineIt can be affected by some medications. For example, certain enzyme inducers such as rifampicin and phenytoin can accelerate the metabolism of amlodipine, reducing its blood concentration and efficacy. Conversely, drugs such as cyclosporine may slow down the metabolism of amlodipine, leading to an increase in drug concentrations and triggering adverse effects. Therefore, when combining drugs, it is necessary to avoid the blood concentration being too high or too low due to the interaction between drugs, which affects the efficacy and safety.
Secondly, amlodipine with other drugsAdverse reactions or *** may occur when combined。For example, when amlodipine is combined with thiazide diuretics, adverse effects such as hypokalemia and tachycardia may occur; When combined with verapamil, pharmacological antagonism may occur, reducing efficacy. Therefore, when combining drugs, it is necessary to fully consider the drug interactions and potential *** to avoid adverse reactions and the occurrence of more serious cardiovascular diseases.
Each blood pressure medication is differentand contraindicationsPatients should be aware of the *** and contraindications of the drugs they are taking, and seek medical attention in time in case of adverse reactions**. At the same time, patients should also regularly check whether the function of the cardiovascular system is normal during the period of taking the drug, and detect the adverse reactions of the drug in time.
Finally, the elderly can bring their own electronic blood pressure monitor at home to regularly monitor their blood pressure and detect abnormalities in blood pressure in time. If there is a large increase in blood pressure and drug control is ineffective, it is necessary to seek medical attention in time. Cerebral infarction is a common complication in patients with hypertension, how can the elderly prevent cerebral infarction?
First of all, the elderly should be prevented in terms of diet. Salt is one of the important triggers of high blood pressure, so it should be taken dailySalt intake is kept at 5 gramsWithin. At the same time, you should eat more abundantlyDietary fiberof fruits and vegetables to ensure smooth stools. In addition, proper supplementation of protein and vitamins can also help improve the body's resistance and prevent the occurrence of cerebral infarction.
Secondly, the elderly should be ensuredGet enough sleepAvoid staying up late for long periods of time and getting tired. Good lifestyle habits can improve blood pressure, blood sugar, blood lipids and other indicators, and the corresponding chronic diseases of these indicators are risk factors for cerebral infarction.
In addition, the elderly doGet a moderate amount of exercise every dayto enhance cardiopulmonary function. Elderly people should also have regular physical examinations to understand their physical condition and detect potential health problems in important organs such as the heart and liver as early as possible.
Finally, the occurrence of cerebral infarction often has some precursor symptoms such as:Headache, dizziness, numbness of limbs, blurred visionWait. The elderly should be alert to the appearance of these symptoms and promptly ** the precursor symptoms of cerebral infarction. Early stage can effectively control the progression of the disease and reduce the risk of cerebral infarction.
In addition, for hypertensive patients who have had cerebral infarction, special attention should be paid to choosing antihypertensive drugs and regimens suitable for their condition. When formulating the best plan, the individual differences of patients, the characteristics of the condition and the purpose of the first plan should be fully considered to formulate a scientific, reasonable and safe plan.
At the same time, patients should actively cooperate with the doctor's adviceTake your medication on time and have regular check-upsTimely adjustment of the program to obtain the best results and health protection, only comprehensive attention and preventive measures can effectively reduce the risk of cerebral infarction and maintain good health.
In conclusion, once again, patients with high blood pressure should follow their doctor's advice while taking amlodipineTake your medication on time and in the right amountIf a combination of drugs is required, special attention should be paidDrug-drug interactionsto avoid adverse reactions and seek medical guidance in time. Monitor your blood pressure regularlyand other indicators, actively control other risk factors, if the patient has symptoms of discomfort or suspicion during the period of taking amlodipine, he should seek medical attention in time and inform the doctor of his medication. The prevention of cerebral infarction in the elderly should also start from many aspects, including:Eat a reasonable diet, control underlying diseases, exercise moderately, maintain good work and rest habits, and have regular physical examinationsand the precursor symptoms of cerebral infarction in a timely manner.
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