This article is from "Nankai Sun Pharmacist", which is used for medical science popularization for reference. Ginkgo biloba leaf and compound Danshen Dripping Pill are commonly used in clinical Chinese patent medicine, with the effect of invigorating blood and removing stasis, regulating qi and relieving pain, mainly used in clinical practice for chest paralysis and heartache caused by blood stasis and obstruction, symptoms of chest tightness, precordial area tingling, coronary heart disease stable angina pectoris see the above syndromes, but for coronary heart disease angina, ginkgo biloba and compound Danshen Dripping Pill can not be used as the main drug, can only be used as a long-term combination drug on the basis of standardization, and can only be used after TCM syndrome differentiation. Generally, it is taken for 4 weeks as a course of treatment, and the duration of medication is extended according to the condition. What is the difference between ginkgo biloba leaf and compound salvia dripping pills? Today, Pharmacist Sun will explain to you one by one:
1.Active Ingredients: The main active ingredients of Ginkgo biloba are Ginkgo flavonols and terpene lactones, both of which are Ginkgo biloba extracts, with clear dosage and data from cell experiments and animal experiments, but there is a lack of more human clinical trial data. The main ingredients of Compound Danshen Dripping Pill are Salvia, Panax notoginseng and borneol, and there is no clear dosage of each component, but there is relatively sufficient human clinical trial data to support it.
2.Pharmacological effects: Ginkgo flavonoid glycols have antioxidant activity, can scavenge oxygen free radicals, anti-inflammatory, inhibit lipid peroxidation, regulate blood lipids, antithrombosis and other effects, terpene lactones have the effects of dilating blood vessels, reducing blood pressure and blood viscosity, improving vascular endothelial function, anti-platelet aggregation, increasing blood and oxygen supply to ischemic tissues, and protecting brain cells. Salvia miltiorrhiza extract has the functions of scavenging oxygen free radicals, inhibiting lipid peroxidation, regulating blood lipids, dilating coronary arteries, increasing coronary blood flow, increasing myocardial blood supply and oxygen supply, protecting ischemic myocardial cells, inhibiting platelet aggregation, and improving microcirculation. Panax notoginseng extract has the effects of dilating blood vessels, lowering blood pressure, improving blood and oxygen supply to myocardium, inhibiting lipid deposition, anti-platelet aggregation, anti-inflammatory and anticoagulant. Borneol is an adjuvant medicine that can promote the entry of the active ingredients of salvia and notoginseng into the tissues, and also has coronary artery dilation and analgesic effects. The pharmacological effects of compound Danshen Dripping Pill are more comprehensive than those of Ginkgo biloba leaves.
3.Clinical application: Clinically, ginkgo biloba is mainly used as an auxiliary for coronary heart disease, stable angina pectoris and stroke**, and has a certain effect on ear circulation disorders such as tinnitus, hearing loss, otogenic vertigo and peripheral circulation disorders such as arterial occlusion, aching limbs, intermittent claudication, and paralysis of hands and feet. Compound Danshen Dripping Pill is mainly used as an adjunct to coronary heart disease angina**, which belongs to the dripping pill dosage form, which can be taken sublingually, quickly absorbed, effective in 3 minutes, and can also be used for first aid of coronary heart disease angina. In addition, clinical trials have shown that compound Danshen Dripping Pill can delay the occurrence and development of diabetic macrovascular complications, reduce the excretion of urine protein, and can be used to prevent and treat diabetic complications, but it cannot be used for cerebrovascular disease**. It should be emphasized that these two drugs can only be used as long-term combination drugs on the basis of standardization, and should not be used separately to avoid delaying the condition.
4.Adverse reactions: Post-marketing adverse reaction monitoring data showed nausea, vomiting, abdominal pain, bloating, diarrhea, abdominal discomfort, dizziness, headache, rash, itching, palpitations, chest tightness, dry mouth, fatigue, allergic reactions and other adverse reactions, and ginkgo biloba leaves showed nausea, vomiting, abdominal pain, bloating, abdominal discomfort, excessive gastric acid, gastrointestinal bleeding, dry mouth, headache, dizziness, rash, itching, allergies, increased or decreased blood pressure, chest tightness, palpitations, bleeding gums, nosebleeds, fatigue and other adverse reactionsBoth drugs have post-marketing adverse reaction monitoring data, and have a good safety, compound Danshen Dripping Pill is a compound preparation, the drug composition is more complex, sometimes the adverse reactions are difficult to distinguish, and more attention should be paid to the use of drugs.