This article is from "Nankai Sun Pharmacist", which is used for medical science popularization for reference. The 6 clinical applications of Xuefu Zhuyu Pill are summarized in one article
1. Chronic obstructive pulmonary disease:
Xuefu Zhuyu Pill is a representative prescription for qi and blood activation, which has the effect of dissolving blood stasis and phlegm, relieving cough and asthma. The peach kernel in the square breaks the blood and stagnates, and the safflower invigorates the blood.
Stasis, the two are the king's medicine. Red peony clears heat and cools blood, dispels stasis and relieves pain; Chuanxiong dispels wind and relieves pain, invigorates blood and qi; Oxknee leads blood downward, invigorates blood circulation, and the three drugs are subordinate drugs to assist Jun medicine to invigorate blood and remove stasis. Rehmannia and Angelica sinensis nourish blood and blood; Citrus aurantium, Platycodon wide-chested qi, cough and phlegm; Bupleurum soothes the liver and relieves depression, and is used with bellflower and citrus aurantium husk to regulate qi and stagnation, and the above 5 flavors of medicine are adjuvants. Licorice invigorates qi and spleen, relieves cough and dissolves phlegm, and coordinates various medicines. Modern pharmacological analysis showed that amygdalin in peach kernel and safflower had vasodilation, fibrinolytic activity and antithrombotic effects, as well as anti-inflammatory and sedative effects. The peony glycosides in red peony, the liguszine in Chuanxiong, and the magnesium phosphate in hyssop have the effects of dilating pulmonary capillaries and arterioles, anti-platelet agglutination, and improving the body's microcirculation; The active ingredients in Rehmannia can strengthen the heart, diuresis, and increase the function of cellular immunity; The ferulic acid in angelica can improve peripheral circulation and have a sedative effect; Citrus aurantium stimulates the smooth muscle of the gastrointestinal tract and reduces the tone of the smooth muscle of the gastrointestinal tract. The saponins in bellflower reflexively promote mucus secretion by the airways, thereby diluting the sputum and making it easier to explode. Saikosaponin has anti-inflammatory, antipyretic, analgesic, antitussive and other effects. Licorice flavonoids have obvious cough and expectorant effects.
Xuefu Zhuyu Pill assists in chronic obstructive pulmonary disease, can promote lung microcirculation, reduce inflammation, and improve lung function and blood oxygenation.
2. Coronary heart disease angina:
The blood house chases the stasis pill and the blood nourishes the yin; Platycodon dissolves phlegm and disperses qi; Licorice blends all kinds of medicines, and introduces medicines into menstruation; Citrus aurantium organizes qi and conducts qi, one rises and one falls, and adjusts the gas engine; Bupleurum soothes the liver. According to modern pharmacological research, Chuanxiong, Salvia miltiorrhizae and Angelica sinensis can inhibit platelet aggregation, anti-thrombosis, promote fibrinolysis, dilate coronary blood vessels, and improve microcirculation; Salvia miltiorrhiza and Chuanxiong can scavenge oxygen free radicals and resist lipid peroxidation, increasing myocardial oxygen supply. Xuefu Zhuyu Pill mainly plays the role of invigorating blood and removing blood stasis, clearing channels and relieving pain. Xuefu Zhuyu Pill ** coronary heart disease angina pectoris, can improve the patient, reduce the frequency of attacks, and improve the ischemic manifestations of ECG.
3. Hyperlipidemia:
In the Xuefu Zhuyu Pill formula, Angelica sinensis, Chuanxiong, safflower, and peach kernel are the main drugs for turbidity and stasis and lipid reduction; Oxknee dispels stasis and goes down to Tongli blood, taking its meaning of "qi is handsome for blood, and qi is bloody"; With Bupleurum soothing the liver and relieving depression, regulating qi and relieving stress, and relaxing emotions. Citrus aurantium and bellflower have a wide chest and qi, and the qi and blood are unimpeded; Raw land cools serum heat, dispels stasis; Gan Zhang reconciles all medicines. It has the effect of invigorating blood, dispelling blood stasis and soothing the liver, relieving depression and regulating qi and lowering lipids. Modern pharmacological studies have shown that Xuefu Zhuyu Pill has the effects of dilating blood vessels, improving blood flow, inhibiting platelet aggregation, improving microcirculation, anticoagulation, lowering blood lipids, inhibiting arteriosclerosis, and regulating autonomic nerve function.
4. High blood pressure:
Xuefu Zhuyu Pill is a famous prescription for blood circulation and blood stasis in traditional Chinese medicine, which is composed of peach red four things decoction and four reverse san plus bellflower and oxknee. Fangzhong peach red Siwu soup invigorates blood and dissolves blood stasis, the four reverses disperse and loosen the liver and regulate qi, the bellflower opens the chest and diaphragm qi, and the ox knee guides blood stasis and blood down. This prescription is mainly used for the treatment of thoracic and diaphragmatic blood stasis and blood stasis lesions, and at the same time, it also has a good effect on systemic blood stasis and qi stagnation syndrome. Modern clinical application of this prescription** cardiovascular diseases are common, as long as there is a clinical syndrome differentiation and blood stasis, this prescription can be used as the main or secondary prescription for addition and subtraction**, and the effect is quite good. The test showed that angelica, peach kernel, safflower, red peony, Chuanxiong and other blood-invigorating and stasis drugs in this formula can inhibit platelet function, antagonize platelet aggregation caused by a variety of inducers, delay blood coagulation, promote thrombolysis, significantly improve blood rheology, etc., thereby improving the blood system of patients with hypertension with blood stasis syndrome, so it has a significant effect on fundamentally regulating the vascular tone system, lowering blood pressure and maintaining blood pressure stability.
Xuefu Zhuyu Pill can improve the effect of lowering blood pressure and stabilizing blood pressure levels, especially for patients with vascular endothelial function, which can increase serum NO concentration and reduce plasma ET-1 level.
5. Insomnia: Xuefu Zhuyu Pill is made of four reverse san (citrus aurantium citrus aurantium shell) and peach four things Tongjia bellflower and Sichuan oxknee. Peach red four-thing soup nourishes blood and invigorates blood, and dissolves qi and stasis; The four reverses disperse and regulate the liver qi, so that the blood flow is not hindered; Platycodon with ox knee makes the qi and blood rise and fall in an orderly manner, and the three focal points are open inside and outside, left and right, up and down. The combination of medicines, nourishing and activating blood, dissolving blood stasis, lifting and lowering in an orderly manner, and making the three focal passes. Modern medicine believes that insomnia can make capillaries narrow and spasm, causing cerebral cortex ischemia and hypoxia, while Xuefu Zhuyu Pill can improve intracranial capillary permeability and increase oxygen reserves.
6. Cerebral infarction
Xuefu Zhuyu Pill uses peach kernels, safflower, Chuanxiong, and red peony to invigorate blood stasis, and cooperate with Angelica sinensis and Shengdi to invigorate blood and nourish blood, so that blood stasis can go without hurting blood; Bupleurum and citrus aurantium soothe the liver and regulate qi, so that qi is bloody; Oxknee breaks the stasis through the meridians, leads the blood stasis downward, the bellflower enters the lung meridian, and the medicine for the flowers and boats leads the medicine upward, and the oxknee leads the blood stasis downward, one rises and one falls, making the qi and blood easier to run; Licorice slows down the urgency, and the veins are cleared to reconcile the medicines.
Modern pharmacological studies have shown that peach kernel has anticoagulant and antithrombotic effects, and has an ameliorating effect on myocardial ischemic injury and cerebral vascular activity. Angelica sinensis has the effect of inhibiting platelet aggregation and anticoagulation. Safflower has the effect of dilating the coronary arteries, which can improve the blood flow of the arteries, reduce the resistance of blood vessels, and have antiplatelet aggregation and antithrombotic effects. The active ingredients of Chuanxiong, such as ligustrazine and ferulic acid, have the ability to scavenge oxygen free radicals and alleviate them.
Ca2+ overload, protection of vascular endothelial cells, vasodilation, inhibition of apoptosis and hypertrophy, regulation of immune status, anti-platelet aggregation and thrombosis, affect the expression of a variety of cytokines, etc., so as to play a role in multi-system, multi-organ and multi-disease syndrome. Red peony can inhibit lipid peroxidation, have a protective effect on focal cerebral ischemia-reperfusion injury, reduce the infarct area of brain tissue, significantly increase the activity of Na+-K+-ATPase and Ca2+-ATPase in ischemic brain tissue, and improve the energy metabolism of brain tissue after infarction. The combination of various drugs can clinically control the infarct area, protect cardiovascular and cerebrovascular vessels and cells, and improve nerve function.