Like this article, you will be healthier and more blessed this year
In 2024, with the hot screening of the Chinese New Year film "Hot and Hot", Jia Ling, who lost 100 pounds, made netizens shout "It's so inspirational"!
The call for national fitness has also reached its peak, and everyone's health awareness will be hot and hot in 2024!
on the Internet.
The importance of enzymes to the human bodyEnzymes play a vital role in the human body.
They are involved in many biochemical reactions like digesting food, synthesizing new molecules, breaking down old molecules, etc. The presence of enzymes allows these reactions to be carried out at a relatively high rate under the right conditions, thus maintaining the normal physiological functions of the human body.
The question is, can enzymes help with fat loss?
The answer is, yes!!
A team of researchers from the University of Michigan's Life Sciences Research Institute has discovered a new way to reduce obesity and related health diseases in mice, namely:Fat loss is achieved by blocking the activity of an enzyme within fat cells。The study was published in the journal Nature Metabolism on January 17, 2022, under the title "Histone Deacetylase 6 Inhibition Restores Leptin Sensitivity and Reduces Obesity".
At the heart of this research is "histone deacetylase 6 (HDAC6)". This is a protease, and researchers have found that by inhibiting its activity, it can improve the brain's ability to perceive lipid-reducing hormone, a hormone that regulates appetite and energy expenditure, resulting in a reduction in fat accumulation.
When an animal accumulates too much energy in its body and stores it in the form of fat, fat cells release more leptin into the blood circulation.
Leptin is a hormone that helps the body restore energy balance by sending signals to the brain to reduce appetite and increase calorie burning. However, in some cases, the brain may have a reduced response to leptin, leading to obesity and related health problems.
on the Internet.
When this effect of leptin was first discovered, it was thought that it would be a panacea for obesity," said Iin Akir of the University of Michigan Institute for Life Sciences. "If leptin can reduce food intake and increase energy burning, then more leptin should help reduce obesity rates. But it turns out that this is not the case. ”
The problem is that as obesity increases, the body becomes insensitive to leptin, so even an increase in circulating leptin levels does not alter appetite or energy expenditure. This is true for both rats and humans.
Akir and his colleagues have now found a way to make mice more sensitive to the leptin their bodies already produce, leading to weight loss and improved metabolic health.
The researchers used a compound that inhibits HDAC6 to feed obese mice on a high-fat diet.
Within a few weeks, the mice lost nearly 25% of their body weight; Unlike the weight loss that often occurs when calorie restriction, the weight loss comes almost entirely from adipose tissue (50% reduction in fat mass) with little to no loss of lean muscle mass.
The team also observed a significant improvement in the overall metabolic health of the mice. They did not experience the reduction in energy expenditure that usually accompanies a decrease in food intake, and they both experienced improvements in liver health and glucose tolerance, suggesting that they were less likely to develop diabetes.
Lean mice with the same compound** did not lose weight, nor did obese mice genetically unable to produce leptin. These results confirm that HDAC6 inhibition must already present high levels of leptin to reduce obesity and that altering HDAC6 activity can modulate body weight by increasing sensitivity to natural leptin.
While the results in mice are encouraging, Chakir stresses that these findings are still a long way from translating to human obesity**.
This study further confirms the critical role of HDAC6 in obesity and related health diseases, and demonstrates the feasibility of reducing obesity by inhibiting HDAC6 activity. This provides a new idea for the development of new anti-obesity drugs, which is expected to bring breakthroughs to obesity and related metabolic diseases. However, further research is needed to validate the effects of these findings in humans and determine the best best strategy.
2024, I wish you all,
Eat it well,
smoothly.