One of the popular science series of life sciences The relationship between aging and cells
The content of this popular science is in: Xi'an Microdynamic Cell Development Industrial Base.
Issue 1: The Basic Concepts of Aging
Definition and classification of aging.
1.Definition of aging.
Aging refers to the phenomenon of the body's physiological and psychological adaptation to the environment gradually decreasing, gradually tending to die. It is a natural and irreversible biological process that involves a wide range of changes at the physiological and molecular levels. Aging is not a single event, but a progressive, multifaceted stage of life.
2.Classification of aging.
Senescence can be divided into two broad categories: physiological senescence and pathological senescence.
2.1 Physiological aging.
Physiological aging is a natural physiological degeneration process that occurs after maturity. It is characterized by loss of elasticity, decreased bone density, vision and hearing loss, and more. This type of aging is mainly caused by natural changes in gene expression and cell function.
2.2 Pathological aging.
Pathologic senescence is a phenomenon of aging caused by various diseases and abnormalities. Different from physiological aging, pathological aging is characterized by suddenness and accelerated process. Common pathological aging factors include chronic diseases, inflammation, genetic mutations, etc.
3.The relationship between cells and aging.
Cells play a key role in the aging process. Cell-level changes such as DNA damage, telomere depletion, and loss of protein homeostasis are hallmarks of aging. Understanding the role of cells in aging can help to gain insight into the methods and science behind anti-aging.
Aging is a complex biological process that is closely related to the functions and mechanisms of cells. Scientists have conducted in-depth research in the field of aging and proposed twelve hallmarks of aging, including indicators of DNA instability, telomere depletion, epigenetic changes, loss of protein homeostasis, dysregulation of nutrient induction, and mitochondrial function. These markers reveal molecular and cytological changes in cells during aging.
The senescence mechanism of cells is mainly influenced by DNA damage. Although cells have a mechanism to repair damaged DNA, once this repair mechanism is compromised, the cells and the body will accelerate aging. For example, patients with Werner syndrome exhibit features of accelerated aging due to defects in their repair mechanisms.
When it comes to anti-aging, in addition to exercise being considered one of the most effective ways. The latest research suggests that precise stem cell delivery can also delay brain aging, slow down the progression of cognitive impairment, and help maintain the body's overall health. Therefore, the anti-aging of cells is the essence of human anti-aging.
In the following popular science series, we will delve into the role of cells, the molecular mechanisms of aging, and the scientific methods of conservation. Please pay attention to the follow-up popular science content and explore the mysteries of biology together.