Glucosamine is a natural amino monosaccharide that is necessary for the synthesis of proteoglycans in the cartilage matrix of human joints. It is formed by the substitution of a hydroxyl group of glucose by an amino group, which is easily soluble in water and hydrophilic solvents. It is known as "joint lubrication protector". At present, there are two kinds of glucosamine hydrochloride and glucosamine sulfate on the market, what is the difference between these two? Which is better, ammonia hydrochloride or ammonia sulfate?
First, read the manual
Glycaminosamine hydrochloride has a wider range of indications:Ammonia hydrochloride is used for:Prevention and**For osteoarthritis in all parts of the body, ammonia sulfate is used only for primary and secondary osteoarthritis.
Amino sugar hydrochloride is large in size, which is more convenient to take:In terms of clinical efficacy, evidence-based evidence supports that the amount of glucosamine should be 1Only above 5g can effectively alleviate the symptoms of osteoarthritis and alleviate the progression. If taking glucosamine hydrochloride (075g tablets) only need 2 tablets per day, while taking ammonia sulfate (025g capsules) requires approximately 6 capsules per day.
Ammonia hydrochloride is safer:Ammonia hydrochloride, green label OTC, has higher safety and is more widely used by a wider range of people.
Second, look at the chemical formula
From the above chemical formula, we can know that most glucosamine sulfate is a mixture formed by adding sodium sulfate (or potassium) on the basis of glucosamine hydrochloride, which is equivalent to containing sodium chloride (potassium) up to 20%, which greatly reduces the proportion of glucosamine sulfate, so the purity of glucosamine sulfate can only be close to 80%, while the purity of glucosamine hydrochloride can be as high as 99%.
Third, look at the curative effect
Efficacy is consistent:From a pharmaceutical point of view, when absorbed in gastric juice (a large amount of hydrochloric acid will actually turn "ammonia sulfate" into "glucosamine hydrochloride") and intestinal fluid, they are indiscriminately decomposed into glucosamine and acid (hydrochloric acid or sulfuric acid), and then glucosamine alone (without hydrochloric acid or sulfuric acid) is absorbed into the bloodstream and reaches the joint cavity. Therefore, whether it is ammonia hydrochloride or ammonia sulfate, they are all floating clouds, and the heroes who really play a role (ammonia sugar) do not ask about their origin (ammonia hydrochloride or ammonia sulfate).
Some manufacturers claim that ammonia sulfate sugar has a good crystalline type, which is conducive to dissolution and absorption. In fact, all kinds of glucosamine eventually dissolve in gastric juice and intestinal juice, and are eventually absorbed as glucosamine. At present, all kinds of ammonia sugar have an absorption rate of more than 90%, and many literature studies at home and abroad have also confirmed that there is no difference in bioavailability (degree of absorption) and average peak plasma concentration (speed of absorption) between the two. Therefore, the common people should not be deceived by this kind of "academic flag" fooling, and believe that all kinds of glucosamine approved by the State Food and Drug Administration are safe and effective.
To sum up: glucosamine hydrochloride and glucosamine sulfate have the same efficacy, butGlucosamine hydrochloride is more pure, more sufficient, has a wider range of indications, and is safer.