When it comes to liver fibrosis and cirrhosis, many people feel nervous when they hear this term, especially some people who already have chronic liver disease.
So, what exactly is liver fibrosis all about? What to do if you have fibrosis? Can liver fibrosis be cured? Let's take a look.
What is liver fibrosis?
The essence of liver fibrosis is a dynamic process of chronic liver damage and repair, that is, on the one hand, the liver is continuously damaged by external sources including hepatitis virus, alcohol, drugs, etc., and on the other hand, the liver is constantly repaired due to its strong regenerative function.
It should be noted that fatty liver is a manifestation of liver damage and one of the important causes of liver fibrosis, which cannot be ignored.
From the perspective of **, this stage of liver fibrosis is still reversible. That is, it is possible to reverse it positively. Once liver fibrosis progresses to the cirrhosis stage, the best chance of ** is basically lost.
How is liver fibrosis diagnosed early?
At present, under medical conditions, the "gold standard" for the diagnosis of liver fibrosis is still percutaneous liver biopsy. It can directly and accurately diagnose liver fibrosis, assess its severity, and provide a basis for **.
Of course, this method of testing is invasive and not acceptable to everyone. At this stage, there are also some non-invasive examination methods to choose from, such as serum molecular markers, ultrasound elastic measurement, magnetic elastography, etc.
How is liver fibrosis**?
The methods of liver fibrosis mainly include primary disease, drugs that control hepatic stellate cells (HSC) and regulate the synthesis and degradation balance of extracellular matrix (ECM).
Note: Reasonable antifibrosis** can reverse or reduce the progression of liver fibrosis and reduce the occurrence of cirrhosis. The sooner** the better, and there is a chance that liver fibrosis will be completely reversed.
1. **Primary disease.
The ** that causes liver fibrosis is more complex, and some diseases such as chronic viral hepatitis, alcoholic hepatitis, and drug-induced hepatitis can cause liver fibrosis.
Liver fibrosis caused by different ** will also be different**. And antifibrosis** needs to last a long time because liver fibrosis is a chronic process.
For example, for the control of chronic viral hepatitis to develop into liver fibrosis and cirrhosis, antiviral drugs** can be selected as the main means; In the case of alcoholic liver disease, early liver fibrosis can be significantly improved by abstaining from alcohol in time.
2. Inhibit HSC activation.
A key step in the process of liver fibrosis is HSC activation. Based on this, if activated HSCs can be reversed to a resting state, it is possible to end and reverse the process of liver fibrosis.
3. Inhibit the synthesis of ECM and promote its degradation.
According to the nature of liver fibrosis, if it can inhibit ECM synthesis or promote its degradation, this may also be a good method of liver fibrosis.
However, this study is still in the animal experimental stage, and there is no suitable drug for clinical use.
4. Reduce inflammation and immune response.
For some types of autoimmune liver disease, steroids may be used**; Ursodeoxycholic acid** cholestatic liver disease has also achieved good results.
Brief summary. After the identification of liver fibrosis, early diagnosis and diagnosis is the top priority and the key. For liver fibrosis, we need to emphasize the synthesis of the primary disease.
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