Mannose on the surface of many common pathogens is one"Red flags"This signal is absent from healthy human cells and tissues, and it activates the lectin activation pathway of the complement system"Bombing"Pathogen invaders. In addition to complement, macrophages can sense invasion. When mannose is captured by receptors, macrophages are removed from a bored one"Garbage collectors"Become one"Professional foodie"or"Angry killer"to defend against microbial attacks.
Mannose glycosylation is also one of the cancer cells"Logos"。Mannose properties have been evaluated to determine their potential for targeted and broad-spectrum microbial inhibition, as well as cancer diagnostics or **. Some of the research work is listed and discussed below.
The tested aptamer has a high affinity and some inhibition of the spike protein of SARS-CoV-2 and the envelope protein GP120 of HIV. At the same time, they can specifically recognize cancer cells and not normal cells.
Photothermal** has the potential to defeat cancer resistance. To make it cancer-selective, the nanoparticles used in ** are equipped with mannose as a targeting unit. Data suggest that photothermal** can be used for precise diagnosis of tumors.
TAM is an infiltrating macrophage in tumor tissue and is the most important component of tumor tissue. They play an important role in the immunosuppressive tumor microenvironment (TME) and resistance to chemotherapeutic agents and nanomedicines, so they are becoming targets for cancer by polarizing to an M1-like phenotype or depletion.
A Study of Mannose-Modified Nanocarrier-Targeted TAM in Solid Tumors**.
If loaded with appropriate cargo, these carriers can be used for prognosis or ** purposes. To achieve precision chemotherapy, a team of researchers developed mannose-modified liposomes that co-loaded ZOL and DOX, and the results showed that the anti-cancer effect was significantly enhanced by the consumption of TAM.
As mentioned earlier, glycations associated with cancer include mannosylation, which is found to be cancerous"Logos", which is a treasure trove for the development of pan-tumor drugs. **FC is a agglutinating antibody constructed by fusing sugar-binding lectin with human IgG1, which significantly limits tumor growth in the model, providing POC evidence that mannose in glycocalyx in cancer cells can be a pan-tumor drug target.
In normal mammalian tissues, mannose is rarely used for glycolysis, which makes mannose a type of use in cancer**"Sweet"choice, as in the fight against pathogens.
With an unrivaled approach to single B antibody discovery and a unique antigen design strategy, DetaiBio is overcoming the low immunogenicity of vitamins, toxins, and sugars to discover high-quality antibodies against these antigens to enable cancer replacement** and in vitro diagnostic (IVD) upgrades. Please contact us to learn more about how we can help.