Recently, the news that actor Wu Xudong suffered from a malignant tumor has aroused the attention and sympathy of netizens. Wu Xudong has starred in movies such as "Operation Mekong" and is known for his tough guy image. He had a mysterious lump on his right leg that lasted for 16 years, and after examination, he was diagnosed with a rare liposarcoma, and faced surgery to have his leg bones sawed off, blood vessels replaced, and he may even lose the ability to walk.
Such an encounter makes people sigh that cancer is really a ruthless and ruthless killer, regardless of age, gender, or occupation, and can take our health and lives at any time.
Liposarcoma is a malignant tumor that occurs in adipose tissue and is a type of soft tissue sarcoma. Soft tissue sarcoma refers to malignant tumors that occur in soft tissues such as muscle, fat, nerves, blood vessels, connective tissues, etc., accounting for 1% to 2% of all malignant tumors. Liposarcoma is the most common type of soft tissue sarcoma, accounting for 15% to 20% of soft tissue sarcomas.
The ** of liposarcoma is currently unclear and may be related to genetic factors, trauma, radiation, chronic inflammation, etc. Liposarcoma can occur anywhere throughout the body, but the most common sites are the extremities and abdomen.
The clinical manifestations of liposarcoma are mainly local masses, and the size, shape, texture, and activity of the masses vary depending on the type, location, and degree of invasion of the tumor. In general, the larger, more irregular, harder, more fixed the lump, and the easier it is to compress the surrounding tissue, the more likely it is to be malignant. Liposarcoma may also have complications such as pain, ulcers, bleeding, infection, metastasis, etc., which seriously affects the quality of life and prognosis of patients.
Liposarcoma is a highly malignant tumour with the following characteristics:
The growth rate is fast, and it is easy to invade surrounding tissues and organs, causing dysfunction and organ failure.
It has strong metastatic ability and is easy to metastasize to distant parts through blood or lymph, such as lungs, liver, bones, brain, etc., forming multiple tumor foci, increasing the difficulty and complexity of the project.
* High rate, even if the primary tumor is removed by surgery, there is a possibility that the tumor will reoccur in the same site or at another site, and repeated surgery or other ** will be required.
*Poor efficacy, due to the diversity and complexity of the biological behavior and molecular characteristics of liposarcoma, there is currently no specific and effective targeting**, and the sensitivity of chemotherapy and radiotherapy is not high, resulting in **unsatisfactory effect and poor prognosis.
Therefore, liposarcoma is a high-risk tumor that needs to be taken seriously and promptly**.
Surgery**. It is the preferred method for liposarcoma, with the aim of removing the tumor and surrounding normal tissue as much as possible, preventing the remnants of the tumor.
Chemistry**. It is an adjuvant method for liposarcoma, which aims to kill or inhibit the growth and metastasis of tumor cells and improve the success rate and prognosis of surgery. Chemistry can be done before surgery to reduce the size of the tumour and make surgery less difficult and traumatic, or it can be done after surgery to destroy possible residual tumor cells and reduce the risk of metastasis.
Radiation**. It is another adjuvant method of liposarcoma, which aims to use high-energy rays to destroy the DNA of tumor cells, so that they lose their ability to grow and lose their ability, so as to achieve the purpose of controlling tumors. Radiation** can be performed before surgery to reduce the size of the tumor and increase the resection rate of surgery, or it can be performed after surgery to reduce the ** and metastasis of the tumor and improve survival.
Targeting**. It is a new method of liposarcoma, which aims to design specific drugs for specific molecular markers of tumor cells, such as receptors, enzymes, signaling pathways, etc., to block the growth and metastasis of tumor cells while reducing damage to normal cells. Drugs and regimens targeting ** should be selected based on the molecular characteristics and sensitivity of the tumor, but the efficacy and safety of targeting ** need further research and verification.