Painkillers, as a common medication, are widely used to relieve a variety of pain symptoms. However, long-term abuse of painkillers can pose serious health risks, one of which is stomach perforation. So, why does taking painkillers for a long time cause stomach perforation?
First, we need to understand the mechanism of action of painkillers. Painkillers mainly relieve pain by inhibiting prostaglandin synthesis in the body. However, prostaglandins not only play a role in pain conduction, but are also involved in physiological processes that protect the gastric mucosa. Therefore, long-term use of analgesics in large quantities inhibits the production of prostaglandins, leading to a weakening of the protective effect of the gastric mucosa.
Second, painkillers may also cause an increase in stomach acid secretion. Gastric acid is an important component in digesting food, but too much gastric acid can erode the gastric mucosa, causing gastric ulcers and other pathologies. Long-term use of painkillers, especially on an empty stomach, may worsen the damage of stomach acid to the gastric mucosa.
In addition, painkillers may affect the normal peristalsis of the gastrointestinal tract. Gastrointestinal motility aids in the digestion and absorption of food, and long-term use of painkillers may interfere with this normal physiological process, leading to gastrointestinal dysfunction and increasing the risk of gastric perforation.
In summary, the reasons for long-term use of painkillers that may lead to gastric perforation mainly include inhibition of gastric mucosal protection, increased gastric acid secretion and interference with gastrointestinal peristalsis. Therefore, we should follow the doctor's advice when using painkillers and avoid long-term heavy use to protect our stomach health.
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