A 100-year adventure with Sophora sophora: 400 years of prescriptions, lasting and new
At the end of the Ming Dynasty and the beginning of the Qing Dynasty, during the Chongzhen period, the plague broke out in the Shangdang area (now Changzhi, Shanxi), and the infected people died one after another, almost to the point of ten rooms and nine empty rooms[1]. Liu Tianshun, a famous local doctor (the prototype of the miracle doctor Xilaile), combined with the ancestral prescription and the epidemic situation at that time, successfully developed the "Sophora Ginseng Soup". He carefully selected precious Chinese medicinal materials such as Sophora radix, and strictly followed the principle of compatibility of traditional Chinese medicine with the envoys of the monarch and ministers, and put these medicinal materials into the well according to the precise proportion. The people drank and bathed in the water, and the plague was curbed. According to incomplete statistics, this prescription saved at least half a million lives.
In the past 6 years, Chinese patent medicines with Sophora radix as the king medicine have shown a strong growth momentum, with an average annual growth rate of more than 1060%, but the proportion of improved new drugs and replicas of ancient classic Chinese medicines is only 06%[2], benefiting from the modern medicinal value of the century-old formula and the huge potential of the market, Zhendong spared no expense to purchase this formula, and after in-depth research and appropriate improvement, it was successfully applied to the research and development of traditional Chinese medicine washing and care products.
Exploration and discovery by pharmacists: led by expertsExplore new knowledge
Sophora sophora has a unique mechanistic principle in biological targets. Its active ingredients can act on multiple targets (matrine, regulate intracellular signal transduction pathways, affect gene expression and regulation, so as to exert anti-inflammatory, antioxidant, anti-tumor and other pharmacological effects. These mechanism principles provide a theoretical basis for the application of Sophora sophora in diseases and tumors.
Zhendong Health has reached in-depth strategic cooperation with dozens of world's top scientific research institutions such as Anderson in the United States, Adelaide in Australia, China Academy of Chinese Medical Sciences, Peking University and so on. The Sino-Australian Molecular Chinese Medicine Research Center was established in Australia, and the University of Adelaide jointly established the only international pharmaceutical cooperation research center of the Ministry of Science and Technology of the People's Republic of China - Jin Pharmaceutical Engineering Laboratory, and cooperated with international institutions such as the Dutch SU Biomedical Company to jointly explore the application of Sophora radix and promote the development and innovation of the pharmaceutical field.
In response to the innovation and improvement of ancient prescriptions, Zhendong Health has assembled a professional team composed of a number of Chinese medicine experts and modern medical researchers, with 11 doctors, 30 well-known experts and 200 R&D personnel. It is worth mentioning that we are honored to invite a number of top experts to serve as cooperation consultants, under the guidance of many well-known experts such as Ye Zuguang, Wang Zhimin, Huang Luqi, academicians of the Chinese Academy of Engineering, Lin Hongsheng, academic leader of the China Academy of Traditional Chinese Medicine, and other well-known experts, the application of Sophora sophora in the field of ** and tumors has made new progress, and combined with modern medical concepts and technical means to scientifically and systematically improve the ancient formula.
In the process of improvement, the team first conducted an in-depth chemical analysis of the ancient formula, clarified its pharmacodynamic components and mechanism of action, and then used modern pharmaceutical technology and strict quality control methods to optimize and standardize the original formula, which significantly improved the stability and reliability of the Sophora sophora formula.
Anti-inflammatory, antibacterial, dispelling wind and fire, clearing away heat and dampness.
Anti-itching, anti-inflammatory, solid barrier.
Natural, safe, 0 burden.
Sophora is no different from the best choice.
Sophora radix has been circulating for 100 years as an important raw material for inhibiting inflammation, and researchers have taken this as a pilot to develop Sophora sophora antibacterial liquid. The antibacterial rate of the product is as high as 999%, won the national patent (a traditional Chinese medicine antibacterial cleaning care solution and its preparation method), and passed the HPV virus inactivation test. This further strengthened the scientific research team's strategic decision to conduct in-depth research and development of Sophora sophora.
20 years of perseverance on the road of planting: deep cultivationPractice for the future
In the R&D and production of traditional Chinese medicine skin care products, raw materials are the core elements that determine the efficacy. Historically, Zhendong has not hesitated to destroy products worth 3 million due to strict raw material standards, and this case still has a profound warning effect today. At that time, even though the product had passed the test of the State Food and Drug Administration for many times, the internal quality inspection found that the color was uneven, which was caused by the quality of the raw materials after verification, even if the efficacy of the drug was not affected in any way, but the chairman Li Anping still resolutely destroyed the product worth more than 3 million, which is also a typical case of our extreme requirements for raw materials and products.
However, due to the weak source production support system of small growers, the lack of a perfect quality traceability system, coupled with multiple factors such as the increase in the cost of Chinese herbal medicines and the cost of medicines, the market chaos of Chinese herbal medicines is frequent: the loss of authenticity of medicinal materials, the failure to follow the seasonal harvest rules, the serious exceedance of pesticide residues, fumigation and sulfur processing, doping, and other phenomena abound. There are many potential safety hazards, less standardization, and uneven quality, which affects the effect of the product.
Chinese herbal medicine is the source, in order to ensure the high quality of raw materials, Zhendong Health adheres to the control from the source, and began 20 years of Chinese herbal medicine planting, from the acquisition of Jinjing Pharmaceutical to enter the traditional Chinese medicine industry to the beginning of large-scale planting of Sophora sophora, after more than 20 years of "deep cultivation", Zhendong Health provides a solid raw material guarantee for product research and development.
In order to ensure the quality and safety of Chinese herbal medicines and decoction pieces in every link of production and circulation, Zhendong independently developed a traceability control system for the whole industrial chain of Chinese herbal medicines, which was first applied nationwide, realizing the whole process of tracking from breeding, planting, storage, processing, transportation to product development and marketing, which also ensures the transparency and standardization of the whole process of Chinese herbal medicine raw materials such as Sophora radix, and provides guarantee for the quality of Chinese herbal medicines.
In order to screen high-quality Sophora sophora variety resources, Zhendong has carried out more than 2 years of in-depth research, breeding and in-depth analysis in 15 regions such as Changzhi, Shangluo, Datong, Baoji, Chifeng, etc., and the results show that the content of matrine and oxidized matrine in Zhongtaihang area is as high as 305% (This is a maximum of 15 percentage points), and the quality is significantly better than that of other regions. Based on this finding, Zhendong Group decided to choose Qinxian County, Shanxi Province as the base of Sophora radix to ensure the high quality and stability of the raw materials.
In terms of breeding innovation, Zhendong has successfully cultivated new varieties of high-quality Sophora sophora - Zhendong Sophora Sophora No. 1 and No. 2, and the contents of matrine and oxidized matrine were respectively tested. 1%, which is higher than that of the control group, respectively. 43%, the introduction of new varieties enriched the germplasm resource bank of Sophora sophora ginseng, and provided a guarantee for improving seed quality and building a breeding base for improved seeds.
In terms of standard formulation, Zhendong gave full play to his rich experience and drafted and formulated the "Quality Standard for Seeds of Sophora", which specified the quality requirements of Sophora Sophora seeds in detail from large to small, hierarchical and grading, and provided scientific standards for the evaluation of commodity specifications and grades in the production, circulation and use of Sophora sophora medicinal materials. It effectively regulates the chaos of the Sophora sophora market and leads the standardization process of the whole industry.
As a cold-tolerant, light-loving and shade-tolerant plant, the total alkali content of Sophora sophora is particularly abundant in low temperature environment (2%). 3] After in-depth research, the quality of Sophora sophora produced in the Taihang area at 37 ° north latitude is better (the content of matrine and oxidized matrine is as high as 3.05%, exceeding the national pharmacopoeia standard), therefore, Taihang Mountain has been established as a high-quality planting base for Sophora sophora. As early as 2009, Zhendong Pharmaceutical has passed the GAP (good Agricultural Practices) certification of standardized cultivation of Sophora sophora, and is the only professional planting company in China that has mastered the patented technology of standardized planting of Sophora sophora and successfully promoted and applied it in the field. This move not only realizes the scale, base, industrialization and modernization of Chinese herbal medicine planting, but also demonstrates Zhendong Pharmaceutical's deep commitment and firm practice to the quality control of Chinese herbal medicines.
The growth years of Sophora radix had a significant effect on its component content. 2-year-old, 3-year-old, and 5-year-old Sophora sophora presents different characteristics in terms of composition. Among them, the rhizome of 3-year-old ginseng is the thickest, and the starch content is relatively high, but its active components are low. In contrast, although the net content of the rhizome of 5-year-old ginseng is smaller, the content of bioactive components such as matrine is significantly increased, and can even be as high as 305%, far exceeding the national pharmacopoeia standard. However, because farmers often use weight as the price criterion when selling Sophora sophora, the sophora ginseng circulating in the market is mainly 2-3 year old ginseng. In order to ensure the effect of the product, Zhendong products insist on using 5-year-old Sophora ginseng as raw materials.
From the field to the scientific research laboratory, from the summary of experience to the presentation of scientific research results. After 20 years of trials and hardships, the chairman of Zhendong Group has joined hands with a team of 100 experts to paint the masterpiece "Chinese Sophora Sophora", as the pinnacle of leading the development of the industry, "Chinese Sophora Sophora" not only provides practical guidance for the majority of pharmaceutical farmers, but also points out the direction for the scientific research and development of Sophora sophora.
20 years of experience in Sophora sophora planting.
The industry masterpiece "Chinese Sophora Sophora" came out.
A century-old inheritance of salvation remedies.
Let them firmly believe that Sophora ginseng will be able to shine in the best field.
A scientific rejuvenation journey of Sophora SophoraChinese Sophora sophoraAnti-inflammatory and nourishing skin
Chinese Sophora sophora, anti-inflammatory and nourishing skin. The results of PPI network analysis showed that albumin (ALB), tumor necrosis factor (TNF), myc proto-oncogene alkaline helix transcription factor (MYC), cysteine aspartate protease 3 (CASP3), cyclin D1 (CCND1), CD44 and interleukin-6 (IL-6) were the core targets of matrine's anti-inflammatory effect, and the molecules were docked** The results show that matrine binds stably to key core targets and interacts well[4]. Matrine significantly reduced the expression of cytokines (interleukin-6, interleukin-8,) (p<005), which has a strong anti-inflammatory effect. [5] This opens up a broad prospect for the application of Sophora sophora in the field of ** care.
Therefore, based on the essence of traditional Chinese medicine and with the formula of Sophora Sophora soup as the source of innovation, the research and development of Sophora sophora anti-inflammatory and skin-nourishing products has been fully launched.
The main difference between cosmetics and drugs is that the functional ingredients of cosmetics are percutaneously infiltrated and accumulated in the active layer for the ultimate purpose. Most skincare ingredients need to enter**, act on the surface or enter the epidermis or dermis according to the effectiveness of the product, and accumulate in the area to play a role, without entering the systemic circulation. [6] In order to solve the problem of transdermal absorption of traditional Chinese medicine care products, Zhendong Group cooperated with the University of Adelaide to jointly develop a microemulsification process using its world-leading small molecule research technology.
By changing the molecular structure from raw materials to texture, the macromolecules that were originally difficult to be absorbed are recombined with the principle of similar dissolution, so that the molecular clusters become smaller (the granularity of ordinary emulsion is greater than 100nm, and the particle size of microemulsion pellets is less than 10nm), and compared with ordinary emulsions, the interfacial tension of microemulsion is small, which can reach 10-2mn m - 10-6mn m, which has very strong emulsification and solubilization ability [7], and achieves stable, targeted and reliable transdermal absorption effect. After rigorous experimental verification, our TCM washing and care products have reached 216 times. It effectively solves the problem that traditional Chinese medicine care products are difficult to be absorbed for a long time.
In R&D and production, we treat every link with pharmaceutical-grade standards and attitudes. In order to maximize the anti-inflammatory effect of Sophora sophorra, no raw material stacking and complex chemical additives are made; They insist on the supremacy of quality, do not compromise because of the short-term market, and insist on using the 5-year Sophora sophora as raw materials; In production, we follow GMP (Good Manufacturing Practice) and produce each skin care product in strict accordance with pharmaceutical-grade standards, which is a unique production standard in the cleaning and care industry.
More than 10,000 scientific skin care experiments.
More than 100 SCI articles.
8 national invention patents.
It embodies more than ten years of scientific research innovation and breakthroughs of Zhendong Health.
With Sophora Sophora as the core, researchers have successfully developed a high-quality, high-performance series of Chinese medicine care products, from head to toe, from top to bottom, Sophora Sophora will take care of your skin in an all-round way, so that the skin will present a healthy balance from the inside out!
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