Neurotrophic factor (NGF) is an important nerve cell growth promoter, which plays an indispensable role in the development and maintenance of the nervous system. NGF is mainly synthesized by mature T lymphocytes, monocytes, and basal cells containing small cell bodies, and is a single-chain polypeptide protein with a molecular weight of about 13 kDa.
Catalog No. PA1000-9269
The functions of NGF are mainly manifested in the following aspects:
1.Promote the growth and survival of nerve cells: NGF can promote the growth and differentiation of neurons, help neurons form fine axons and dendrites, and maintain the survival state of neurons.
2.Promote synaptic formation and connection: NGF can increase the density of synaptic connections, promote synaptic formation and regulation, and facilitate information transfer and communication between neurons.
3.Promote memory and learning: NGF can promote the activity of neurons in the brain, enhance the connection between neurons, and help improve the learning and memory ability of people.
The structure of NGF can be basically divided into two functional parts: one is the active structural region and the other is the connecting region. The active structure region is the active center of NGF molecules, which can synthesize NGF from mature T lymphocytes, monocytes and basal cells containing small cell bodies. The junction region is used to connect the receptor so that the receptor can bind to NGF and perform signal transduction.
The biosynthesis of NGF mainly goes through the following steps: the mature MRNANGF precursor is first synthesized in the nucleus, and the MRNANGF is synthesized through the cytoplasm containing more small cell bodies, and the MRNANGF is continuously synthesized to form mature NGF precursors, and the NGF precursors enter the small cell for further maturation, and finally enter the extracellular through secretion and transport.
The recombinant protein of NGF is recombinant of human NGF gene into cells containing the corresponding expression system through genetic engineering technology to achieve large-scale production and extraction. The recombinant NGF protein has the same biological activity and function as native NGF, but with higher purity and stability, making it more suitable for clinical** and research applications.
In conclusion, NGF recombinant protein, as an important nerve cell growth promoter, plays an important role in the development and maintenance of the nervous system. Through the understanding of its basic information and functional structure, we can better understand and apply NGF recombinant protein, promote the growth and survival of nerve cells, promote synaptic formation and connection, improve learning and memory ability, and provide strong support for the prevention and treatment of neurological diseases.