DSPE-MAL phospholipid modification is to esterify distearoylphosphatidylethanolamine (DSPE) and maleic anhydride (MAL) to generate DSPE-MAL, which is then applied to the construction of drug delivery systems. DSPE-MAL phospholipid modification is amphiphilic, that is, it can form stable liposomes in aqueous solution, and at the same time, it can fuse with cell membranes to achieve targeted drug delivery.
2. Application direction of DSPE-MAL phospholipid modification in the field of drug delivery.
1.Antineoplastic drug delivery.
Tumor is one of the diseases that seriously threatens human health, and traditional chemotherapy drugs often have greater toxicity, and as an efficient and low-toxicity drug delivery system, traditional chemotherapy drugs often have a wide range of application prospects in anti-tumor drug delivery. By encapsulating anti-tumor drugs in DSPE-MAL liposomes, targeted delivery to tumor cells can be realized, improving the efficacy of the drug and reducing toxicity
2.Genetic** drug delivery.
Gene is an emerging disease method, but because the biological activity of gene drugs is susceptible to external environmental influences, an efficient and stable gene drug delivery system is required. As a safe and effective gene drug delivery vehicle, DSPE-MAL phospholipid modification can achieve stable encapsulation and targeted delivery of gene drugs, and improve the bioavailability and efficacy of gene drugs.
3.Anti-inflammatory drug delivery.
Inflammation is an important mechanism in the occurrence and development of many diseases, so anti-inflammatory drugs play an important role in the disease**. However, traditional anti-inflammatory drugs tend to have problems such as large *** and low bioavailability. As an efficient and low-toxicity anti-inflammatory drug delivery system, DSPE-MAL phospholipid modification can achieve targeted delivery to inflammatory cells, improve the efficacy of anti-inflammatory drugs and reduce toxicity
4.Construction of targeted nanomedicines.
Targeted nanomedicine refers to the combination of drugs to specific targets to achieve precise delivery and release of drugs. As a commonly used targeted nanomedicine construction technology, DSPE-MAL phospholipid modification can achieve targeted delivery to specific cells by binding to specific antibodies or ligands. This targeted nanomedicine has a wide range of application prospects in major diseases such as cancer and neurodegenerative diseases.