By supplementing the furry child with DrDr. Pettlabs Pet Life Prolonging Cellular Nutrients, after supplementing NMN to increase NAD+ levels, activates the longevity protein Sirtuins family to regulate cell health and homeostasis in dogs.
Sirtuin is a highly conserved deacetylase class from bacteria to humans, and there are 7 recognized members of the sirtuin family in mammals: SIRT1 SIRT7
With different subcellular localization and functions, these proteins play an important role in cell cycle control, maintenance of mitochondrial homeostasis, autophagy, and cell growth regulation.
SIRT1: Metabolism, Immune Response, Aging Regulation, Cardiovascular.
SIRT2: Calorie restriction, markers of cellular senescence.
SIRT3: hepatoprotection, mitochondrial metabolism.
SIRT4: islet function, liver function.
SIRT5: alcohol metabolism, cardiovascular and cerebrovascular metabolism, and neurometabolism.
SIRT6: Repair DNA damage.
SIRT7: Regulates heart cells.
To sum up, what exactly does Sirtuin help with anti-aging
1.DNA damage is thought to be one of the causes of cellular aging, and sirtuin can repair DNA and control inflammation to fight aging.
2.Oxidative stress is one of the causes of aging diseases, and sirtuin can counteract oxidative stress by regulating the level and activity of antioxidant enzymes.
3.Sirtuin can activate longevity-promoting signals (AMPK, FOXO) and inhibit aging signals (mtor).
So you know why sirtuin is called longevity protein.
It's like the lowest level of technology in **, but it's also indispensable
Sirtuin vs. NAD+
Although the Sirtuin family can regulate aging and longevity through various reactions, they adhere to the principle that silence is golden, and most of the time they are not very active or even dormant, and they need NAD+ activation to work actively.
It can be said that without NAD+, all the functions of Sirtuin would not be able to play out.
However, NAD+ will be lost rapidly with age, and exogenous supplementation is required, and the molecular weight of NAD+ is too large to be directly absorbed, so the best way to supplement NAD+ is to supplement NAD+ precursor NMN, so that it can be metabolized into NAD+ in the body, and then activate sirstuins