At present, the use of stem cell reinfusion to improve health has become a new trend pursued by people.
However, under the guidance of various **, there is a point of view that has been widely circulated:"The greater the amount of stem cell reinfusion, the better the effect.
Is this statement accurate?Next, we will reveal the secret of stem cell reinfusion.
One: Stem cell reinfusion is not always better
In fact, just as the recommended dosage is indicated in the drug label, there is also an effective dosage range for stem cell reinfusion.
In 2019, Stem Cells Translational Medicine (Impact Factor: 69) published a study titled "Clinical Trial Trends of Mesenchymal Stem Cells from 2004 to 2018" [1], which confirmed this view.
American scholars analyzed more than 900 clinical trials of mesenchymal stem cells registered in the clinical trial registry of the National Institutes of Health before March 2019.
Scientists from the Stem Cell Research Center at Rutgers University in the United States selected 28 clinical trials involving different doses of stem cells over the past 14 years to determine whether there is an effective dose range for stem cells** while excluding other variables.
The results of the study showed that among the 16 intravenous injection experiments in the statistics, the effective dose of 14 experiments was between 70 million and 1between 900 million cells.
Outside of that range, trials below 70 million doses have often been shown to be ineffective;When the injection amount exceeds 1At 900 million, the efficacy of the trial will not only not improve, but may decrease, and at the same time, it will be accompanied by a higher risk of adverse reactions.
Similar results were found in three intra-articular injection experiments. At this point, the effective dose of stem cells drops to 50 million to 100 million cells. When the research team reduces the injection volume to 10 million or increases the number of cells injected into a single patient, the effect is also affected.
Experimental data (partial) after intravenous infusion of stem cell doses (in millions) were studied
All the statistics point to one conclusion: stem cells** do have an effective dosage range.
At the same time, as one of the important indicators affecting the effect of reinfusion, the researchers also found that the relationship between stem cell dose and efficacy showed an inverted U-shaped state. That is, within a certain range, the more doses, the better, but when the effect reaches the highest point (optimal dose), continuing to increase the dose will not only not bring better efficacy, but may also cause adverse reactions.
So, how do you calculate the optimal dose of stem cells?
2: How to judge the best dose of stem cells?
In fact, stem cells have a wide range of applications in the future, including anti-aging, neurological diseases, cardiovascular and cerebrovascular diseases, degenerative diseases and diabetes, etc., and the corresponding methods for different diseases are different, which affects the use of stem cells. At present, there are at least three dose calculation methods for stem cell products on the market.
The dose is calculated based on the patient's body weight
Temcell is the world's first mesenchymal stem cell product for acute graft-versus-host disease (A**HD) using this calculation method. This drug is indicated for acute graft-versus-host disease caused by hematopoietic stem cells and is administered by intravenous infusion at a dose of 210 cell kg[2].
The dose is calculated based on the area of damage
CARTISTEM is a stem cell product for degenerative arthritis and knee cartilage damage, developed by Medipost, South Korea. The drug consists of neonatal umbilical cord blood mesenchymal stem cells (HUCB-MSC) and sodium hyaluronate and is surgically administered. The dosage used is 2510 cell cm (area of knee cartilage lesion)[3].
The official website of Medipost Co., Ltd. in Seoul, South Korea, publishes instructions for the dosage and use of CARTISTEM.
Fixed dose
Hearticellgram-ami is a mesenchymal stem cell drug** for myocardial infarction and the world's first autologous stem cell** approved for marketing. According to the official instructions, the number of injected cells of the drug can be selected in three fixed doses depending on the patient's weight: 50 million, 70 million, and 90 million [4].
The official website of FCB-Pharmicell in South Korea publishes instructions for the dosage of HearticellGram-AMI.
Therefore, the optimal dose of stem cell reinfusion is not fixed and needs to be adjusted according to the actual situation.
After mastering the relevant knowledge of stem cell reinfusion, everyone should have a more comprehensive understanding of this concept: more infusion is not better, and there is also an effective dosage range for stem cell drugs. Determining the optimal dose requires a combination of factors such as the patient's medical condition, their own condition, and the injection method to arrive at the final answer.
References: 1] Trends in mesenchymal stem cell clinical trials 2004-2018: is efficacy optimal in a narrow dose range?
Wrapping up
As a cutting-edge technology that continues to develop, stem cells themselves are subverting traditional concepts, and cognitive biases are inevitable. The debate over reinfusion is also a reminder that stem cell technology needs to be viewed from a more holistic and rational perspective in order to get the desired results.
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