This article is from "Nankai Sun Pharmacist", which is used for medical science popularization for reference. Can gamma oryzanol be eaten every day?How to eat gamma oryzanol and vitamin B12?Can gamma oryzanol plus vitamin B1 prevent neurasthenia?
Gamma oryzanol is not a vitamin, but a mixture of natural oils, widely found in the epidermis of grains such as brown rice, corn, wheat, wheat bran, etc., the drug gamma oryzanol is extracted from rice bran oil and germ oil, the main components are phytoenol and ferulate, which has antioxidant activity, and can regulate autonomic nerve dysfunction and endocrine balance disorders, improve tension and anxiety, stabilize mood, and is suitable for neurosis, The sedative and hypnotic effect of premenstrual tension syndrome and menopausal syndrome is mainly in regulation, and there is no clear sedative-hypnotic effect, which may be effective for mild insomnia, but almost ineffective for moderate and severe insomnia.
With the increasing clinical use, many clinicians try to use gamma oryzanol** for other diseases, such as gamma oryzanol can regulate autonomic nerve dysfunction, improve myocardial blood supply, reduce myocardial cell excitability, and can be used as an adjunct to angina pectoris and arrhythmia**. Gamma oryzanol can regulate autonomic nerve dysfunction, reduce vagus nerve excitability, inhibit gastric acid secretion, and can be used as an aid to peptic ulcers**. Gamma oryzanol has an anti-aging effect, which can inhibit the formation and diffusion of melanin, lighten dark spots, and can be used in medical cosmetology. Gamma oryzanol has antioxidant effects, can regulate blood lipids, reduce serum total cholesterol, LDL cholesterol and triglyceride levels, and increase serum HDL cholesterol levels, which can be used as an adjunct to dyslipidemia**. It should be noted that the above indications of gamma oryzanol are off-label drugs and must be used under the guidance of a doctor.
Although gamma oryzanol is mainly extracted from natural grain oils, there are few adverse reactions in short-term use according to the conventional dose, and the safety and tolerability are good, but gamma oryzanol is a drug, not a health care product, and the drug has its best course of treatment, long-term or high-dose gamma oryzanol can lead to autonomic nerve dysfunction, nausea, vomiting, bloating, diarrhea, stomach discomfort, indigestion, constipation and other gastrointestinal reactions, as well as chest tightness, chest pain, increased blood pressure, In the same way, long-term or high-dose gamma oryzanol can also lead to endocrine dysfunction, such as breast tenderness, weight gain, and hair loss. Therefore, it is recommended that gamma oryzanol should be taken according to the doctor's instructions and should not be taken every day.
Vitamin B12 is a water-soluble vitamin, which is mainly involved in the metabolism of folic acid in the body, promotes the maturation of red blood cells, maintains the normal hematopoietic function of the body, and can participate in the production of fatty acids, maintain the structure and function of glial cells, protect neuronal cells, and ensure the normal operation of the central nervous system. In addition, vitamin B12 can also participate in the metabolism of homocysteine, reduce the level of homocysteine in the blood, and is mainly used clinically for megaloblastic anemia, and can be used for hyperhomocysteinemia, prevention of cardiovascular and cerebrovascular diseases such as stroke and coronary heart disease.
Gamma oryzanol is a mixture of oils and fats, which has a strong fat solubility, and can be better dissolved and absorbed after mixing with fatty foods, and exert the best efficacy of the drug, therefore, it is recommended to take gamma oryzanol after meals, and appropriately increase the intake of fatty foods, if the symptoms are not reduced after 7 days of medication, it should be stopped. Vitamin B12 is a water-soluble vitamin, with strong water solubility, if taken on an empty stomach, the drug will be quickly absorbed by the small intestine through the stomach, the blood concentration rises rapidly, the drug is quickly excreted through the kidneys with urine, can not be absorbed completely, give full play to the efficacy, if taken after meals, the drug is mixed with food, the absorption rate in the small intestine slows down, which is conducive to more fully exerting the efficacy, therefore, vitamin B12 should also be taken after meals.
Vitamin B1, also known as thiamine, is a water-soluble vitamin necessary to maintain human metabolism, mainly in the form of coenzymes in the human body to participate in the decomposition and metabolism of carbohydrates, protect nerves, promote gastrointestinal peristalsis, increase appetite, and maintain the normal function of the nervous system and digestive system. Vitamin B1 deficiency can lead to oxidation blockage in the body, cause glucose metabolism disorders, accumulate harmful substances such as lactic acid and pyruvate in the body, cause nervous system abnormalities, induce peripheral neuritis, and can also lead to digestive system disorders such as loss of appetite, indigestion, and weight loss.
Neurasthenia is due to long-term excessive pressure, tension and mental fatigue and mental excitability, common tantrums, emotional irritability, sleep disorders, muscle tension and pain and other symptoms, sometimes mild and sometimes severe, generally will last for a long time, can not be completely **, neurasthenia is mainly related to mental factors and personal character. At present, the diagnosis of "neurasthenia" is rarely used in clinical practice, and according to the current diagnostic criteria, neurasthenia can be replaced by a diagnosis such as depression, anxiety or early psychosis.
At present, the main method of neurasthenia is psychological, through psychological counseling, so that patients understand the nature and causes of the disease, so as to gradually get rid of tension, anxiety and depression and other emotions, release stress, neurasthenia patients can use anti-anxiety or antidepressant drugs appropriately under the guidance of doctors, improve anxiety and depression symptoms, relax muscles, and eliminate physical discomfort. Gamma oryzanol can regulate autonomic nerve disorders, relieve tension and anxiety, vitamin B1 has the effect of regulating mental mood, the combination of the two drugs has a certain effect on improving neurasthenia, and is particularly suitable for neurasthenia caused by autonomic nerve disorders, but the efficacy is not exact, and can only be used to assist**.