"2016 China Gout Diagnosis and Treatment Guidelines" has released a data: as of February 2016 statistics, the ratio of men and women to gout patients in China is 15:1, converted, about 93% of gout patients are men, the proportion is very obvious, "10 gout 9 men" statement is not an exaggeration.
But why is it always men who are unlucky when they encounter gout?
This thing starts with the ** of gout!
part 01
Men shed rancidity on hormones.
The pathogenesis of gout is not well understood, but high uric acid is well established**.
The relationship between high uric acid levels and gout is mainly related to the formation and deposition of uric acid crystals. When uric acid reaches a saturated concentration, it crystallizes and deposits in the joints and surrounding tissues, causing inflammation and pain.
Uric acid in the human blood is a waste product produced during metabolism in the body, and according to the body's own plan, one-third of it will be excreted from the feces through the intestines, and the remaining two-thirds will be excreted through the kidneys into urine.
However, the amount of uric acid that the body can hold is limited, up to 1200 mg, and once this balance is broken, the excess uric acid will make waves in the body.
Compared with women, men's bodies are more likely to "accumulate acid".
Source: giphy
Because in the matter of excreting uric acid waste, androgens are a large roadblock, which will reduce the efficiency of uric acid excretion.
Estrogen, on the other hand, can more effectively channel uric acid out of the body and prevent uric acid from "growing" in the body, leading to gout.
However, this also means that once a woman is menopaused, her estrogen level will decline, and she will also become a gout-preferred physique.
part 02
How to eat and drink when gout comes to the door?
01 Diet.
20% of the body's blood uric acid** is found in food, and in clinical practice**, diet plays a key role in controlling gout attacks and managing symptoms.
Low-purine diet: Purines are substances that break down into uric acid in the body. Therefore, people with gout should limit their intake of high-purine foods. These foods include organ meats, seafood, and foods and beverages that are high in sugar.
Increase water intake: Drinking enough water can help with uric acid elimination. It is recommended to drink at least 8 cups of water per day, about 2000-3000ml.
Source: giphy
Control alcohol intake: Alcohol can interfere with the excretion of uric acid and increase the risk of gout attacks. Try to limit alcohol intake, especially beer and spirits.
Increase your intake of low-fat dairy products: Low-fat dairy products are rich in protein but do not lead to the accumulation of purines. Choose from low-fat milk, yogurt, etc.
Moderate intake of vitamin C: Vitamin C may help lower uric acid levels. It can be consumed through fruits, vegetables, or vitamin C supplements.
02 Medication.
1) Emergency Department**.
Western. Within 24 hours, take nonsteroidal drugs (NSAIDs), COX-2 inhibitors (such as celecoxib, meloxicam, etc.), colchicine, or steroid medications. An early, adequate course of treatment is recommended until the acute gouty arthritis is completely resolved, usually taking several days to 2 weeks.
Medicinal herb. The onset is abrupt, mostly manifested as redness, swelling, heat and pain in the joints of the lower limbs, especially in the first metatarsal toehee and big toe joints, and the joints of the lower limbs are heavy, and can also be manifested as redness, swelling, heat and pain in one or more other joints, often accompanied by fever, bad wind, thirst, irritability, yellow urine, and slippery pulse.
Source: giphy
*Mainly to clear away heat and circulation, accompanied by wind and dehumidification products. Commonly used Si Miao Pill plus flavor or white tiger cinnamon branch decoction plus or minus, and often add spleen turbidity and diuretic dehumidification products, one is to prevent spleen deficiency and dampness, the other is to make the evil have a way out, wet from urine.
2) Uric acid-lowering**.
Western. Uric acid lowering is initiated immediately in the acute phase or after symptomatic resolution (> 2 weeks).
Poor uric acid excretion type: benzbromarone, probenecid, etc., exert a urination inducing effect by inhibiting the reabsorption of bromophenol glucosol in urine by the renal tubules, thereby reducing the concentration of uric acid.
Hypersynthesis of uric acid: allopurinol, febuxostat, etc., by inhibiting purine oxidase, the metabolites of the drug slow down the production of uric acid in purine metabolism, resulting in a decrease in uric acid.
Hybrid: The above are used alone or in combination.
Source: giphy
Medicinal herb. After gout enters the chronic stage, it is manifested as swollen and painful joints, unfavorable flexion and extension, or subcutaneous nodules or tophi, thin white or greasy tongue coating, and tight or slow pulse. According to the different feelings of wind, cold and dampness, the clinical manifestations have the characteristics of paralysis, cold paralysis and paralysis.
In view of the characteristics of the three evils of wind, cold and dampness, ** is always based on dispelling wind and cold, dehumidifying and channeling, and coix seed decoction is commonly used to add or subtract. In addition, do not forget to add spleen and dampness and diuretic and dehumidification products, and pay attention to the application of menstrual induction drugs for the upper and lower limbs to improve the efficacy.
In conclusion, regardless of whether it is Chinese or Western, when choosing and using drugs, doctors will consider the patient's specific symptoms, health status, and drug interactions.
Medications** usually need to be adjusted on an individual basis and under the supervision of a doctor.