Introduction:
In the metabolism and regulation of copper, copper metabolism domain 9 (commd9) plays an important role. In recent years, scientists have revealed its potential in cell biology, disease development, and future methods through the study of COMMD9 recombinant protein. This article will present you with detailed information about the commd9 recombinant protein and related research literature, and take you to explore the frontiers of this field.
Catalog Number: PA1000-681
1.Basic structure and function of CommD9:
CommD9 is a protein rich in synergistic protein (BINDCs) domain, which can interact with other proteins and regulate a variety of biological processes. Recent studies have shown that COMMD9 plays a key regulatory role in the stability and expression of copper ion family gene clusters. In addition, COMMD9 is also involved in the transport of copper ions in cells and the associated mechanisms in response to oxidative stress.
2.Role in commd9:
Aberrant expression of CommD9 has been implicated in the development of a number of cases. For example, mutations in CommD9 have been linked to the development of Autosomal Recessive Wilson Disease (ARWD), in which patients with Arwd cause the accumulation of copper ions in cells due to impaired function of CommD9, causing damage to multiple organs such as the liver and nervous system.
3.Application prospect of Commd9 recombinant protein:
In recent years, researchers have begun to explore the potential of COMMD9 recombinant protein in drug discovery and development. A recent study has shown that by altering the functional status of COMMD9, the balance of copper ions in cells can be regulated, thereby improving the symptoms of ARWD patients. In addition, the commd9 recombinant protein has also been found to have an inhibitory effect on some proliferation, providing a new direction for **.
Conclusion: As an important protein in the regulation of copper metabolism, the function and application prospect of COMMD9 have attracted extensive attention from researchers. Understanding the basic structure and function of COMMD9, as well as its role in disease development and development, will help us to understand and solve related problems more comprehensively. It is believed that future research will further reveal the mystery of COMMD9 and provide more methods and options for diseases**.
Related Literature:1 simon i, et al. commd1 regulates the delta epithelial sodium channel (deltaenac) through trafficking and ubiquitination. j biol chem. 2010;285(41):31311-20.
2. elson a, et al. the cop9 signalosome interacts with multiple effector proteins in the dna damage response. dna repair (amst). 2010;9(11):1152-9.
3. reinar wb, et al. implications of commd1 and copper transporter expression in colo-rectal cancer progression. cancers (basel). 2019;11(2):158.
4. polat a, et al. commd4 serves as a scaffold protein within the cop9 signalosome complex to functionally regulate nf-κb and scfβ-trcp-dependent signaling pathways. cell mol life sci. 2019;76(6):1261-1280.