Antimicrobial peptides (AMPS) tend to select for drug resistance, rapid killing, and ideal clinical efficacy against several multidrug-resistant pathogens, showing excellent potential in combating these threats. However, a number of factors limit their clinical application.
Based on the above questions,School of Molecular Medicine, Hangzhou Advanced Research Institute, University of Chinese Academy of SciencesLaiTeam of professorsA tumor-specific nano** platform was constructed, which combined photodynamic (PDT) with epigenetic** to simultaneously activate pyroptosis and CGAS-STING pathways in a photocontrolled manner. The study, titled "Orientationalnanoconjugation with gold endows marked antimicrobial potential anddrugability of ultrashort dipeptides", was published in NanoLetters.
Peptides have multiple functional groups, including amino and sulfhydryl groups, which can immobilize the peptide to gold NPs through electrostatic interactions and au-S coordination covalent bonds, respectively. Considering that covalent coupling is reliable and conjugates are homogeneous, the authors constructed short peptides with N-terminal cysteines that enable them to be coupled to gold via AUS bonds. In order to avoid non-specific reactions with AMP side-chain amino groups, which can affect the peptide orientation on the gold surface and thus potentially reduce antimicrobial activity, the authors limit the length of the peptide to no more than 3 amino acid residues. In addition, the net positive charge of the peptide (provided by lysine arginine) is necessary because the cationic nature of AMP is highly correlated with its antimicrobial activity.
In conclusion, dipeptide (CR) golden NPS has strong bactericidal activity and specificity against Staphylococcus aureus, with a good safety profile and impressive ** effect. The formulation reported in this article may contribute to the development of a universal platform for innovative antimicrobials.
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