Targeting is a novel approach that is highly specific by targeting specific molecular targets in tumor cells. Compared to traditional chemotherapy and radiotherapy, targeting has a better effect and a smaller number of more common targets as follows:
1.Targeting for EGFR gene mutations**.
Epidermal growth factor receptor (EGFR) is a receptor that is highly expressed in lung cancer cells, and its gene mutations are closely related to the occurrence and progression of lung cancer. Targeted** drugs targeting EGFR gene mutations include dacotinib, ametinib, osimertinib, fumetinib, befatinib, etc. These drugs can inhibit the activity of EGFR in lung cancer cells, thereby inhibiting the growth and spread of tumor cells.
2.Targeting for ALK gene mutations**.
Anaplastic lymphoma kinase (ALK) is a gene that is abnormally expressed in lung cancer cells, and its gene mutations are also closely related to the occurrence and progression of lung cancer. Targeted** drugs targeting ALK gene mutations include lorlatinib, alectinib, ceritinib, brigatinib, ensartinib, etc. These drugs can inhibit the activity of ALK in lung cancer cells, thereby inhibiting the growth and spread of tumor cells.
3.Targeting of vascular endothelial growth factor (VEGF)**.
Vascular endothelial growth factor (VEGF) is a factor that promotes tumor angiogenesis and is highly expressed in lung cancer cells. Targeted** drugs against VEGF include bevacizumab, among others. These drugs can inhibit the activity of VEGF in lung cancer cells, thereby inhibiting the production of tumor blood vessels, reducing the nutrition of tumor cells**, and thus inhibiting the growth and spread of tumor cells.
Targeting** has a good effect on advanced lung cancer, which can significantly prolong the survival and improve the quality of life of patients. However, there are also some *** such as rash, diarrhea, fatigue, etc. In addition, long-term use of targeted drugs may lead to the emergence of drug resistance, affecting the effectiveness of drugs. Therefore, when using targeted ** drugs, it is necessary to strictly follow the doctor's instructions, regularly review the imaging to evaluate the efficacy, and report adverse reactions to the doctor in a timely manner.