Whether kidney disease is hereditary or not depends largely on the specific type of disease. Most kidney diseases are not inherited, and only a very small number of non-common kidney diseases are genetically predisposed, such as hereditary polycystic kidney disease, Alport syndrome, thin basement membrane nephropathy, etc.
Hereditary polycystic kidney disease is a relatively common autosomal genetic disease, and its inheritance mode can be divided into autosomal dominant inheritance and autosomal recessive inheritance. Alport syndrome, also known as hereditary nephritis, is a monogenic inheritance disease with chronic kidney damage and ear and eye lesions. Thin basement membrane nephropathy, also known as benign familial hematuria, is a disease whose pathogenesis is not well understood and may be inherited in an autosomal dominant manner.
So when do you need to do genetic testing?
Hereditary kidney disease: Hereditary kidney disease refers to kidney diseases caused by genetic mutations, such as polycystic kidney disease, hereditary nephritis, thin basement membrane nephropathy, etc. These diseases are closely related to genetics, and genetic testing can help identify, progression, and risk of the disease, as well as provide guidance for prevention and prevention.
Primary nephropathy: Primary nephropathy refers to kidney diseases of unknown cause, such as chronic glomerulonephritis, diabetic nephropathy, etc. For these diseases, genetic testing can help identify, provide a basis for diagnosis and identification.
Secondary kidney disease: Secondary kidney disease refers to kidney disease caused by other systemic diseases, such as systemic lupus erythematosus, hypertension, etc. In these cases, genetic testing can help understand the pathogenesis of the disease, the development and risk of the disease, and provide guidance for prevention and prevention.
In general, genetic testing plays an important role in the diagnosis and diagnosis of kidney disease, especially for unidentified diseases such as hereditary kidney disease and primary kidney disease. Through genetic testing, we can better understand the pathogenesis of the disease and provide patients with more personalized programs and life plans.