It's been a year since the world-famous singer Celine Dion opened up last year that she had "stiff man syndrome", which prevented her from showing her angelic voice as she used to, so she canceled a large number of performances.
In late October this year, Celine Dion, who had not appeared for a long time, made a rare public appearance and seemed to be in better health. However, just last week, his sister Claudet Dion revealed to Canada's 7 Days magazine that the Grammy winner is unlikely to return to the stage for the time being, as she has "lost control of her muscles".
It is understood that Celine Dion's theme song "My Heart Will Go On" sung for the movie "Titanic" won the "Song of the Year" and "Production of the Year" awards at the 41st Grammy Awards. And in 2013, Celine Dion took the theme song of the movie "Titanic" "My Heart is Eternal" on the stage of the Spring Festival Gala in the Year of the Snake.
Stiff person syndrome (SPS), first proposed by Moersch and Woltman in 1956, is a clinical comparisonRare progressive autoimmune disease。Patients may develop symptoms early in the course of the diseaseStiffness and spasms usually occur first in the muscles of the feet and trunk, especially in the lower back area, over time, can gradually affect the hands and even the facial area.
Other complications that may occur in patients with this disease include:Severe autonomic disorders and muscle cramps, unexplained falls, fractures and joint dislocations, hypoxemic respiratory failure, post-traumatic stress disorder, pharyngeal muscle spasms leading to esophageal obstruction, etc.
Chief physician Qiu Wei, assistant to the president of the Third Affiliated Hospital of Sun Yat-sen UniversityIntroduction, this disease, also known as "wooden man", is a very rare autoimmune and nervous system disease. of the diseaseFemale patients predominateWhen you see a doctor, you often have a stiff lumbar area like a piece of wood, your legs are difficult to walk, and you are prone to falling when walking.
Clinically, because patients are more likely to see muscle stiffness in the lower back region, it is more commonIt is easily misdiagnosed as a rheumatic immune disease - ankylosing spondylitis。The patient was diagnosed with "hysteria and anxiety" after not getting better, and was finally diagnosed after several rounds to the neurology department.
Some people confuse "stiff person syndrome" with another rare disease, "ALS", but in fact, the two are very different.
ALS, the final outcome of amyotrophic lateral sclerosis, usually results in death from paralysis of the respiratory muscles or a lung infection. Patients with "stiff person syndrome" do not die from this lesion, but they will experience great mental stress due to a significant decrease in their quality of life.
Stiff person syndrome" is characterized by patients with:Positive for GAD65 antibodies can be detected in vivo, but the cause of their GAD65 antibodies is currently inconclusive in the medical community.
Director Qiu Wei said that according to domestic and foreign literature reports, in addition to the abnormalities caused by the nervous system, some patients will also have abnormal blood sugar elevations and other systemic manifestations, and some patients have tumor ......Because the disease is so rare, few cases have been reported globally, and follow-up is inadequate, it needs to be further explored.
Since it is so rare and the research is not deep enough, many people will feel that suffering from "stiff person syndrome" is equivalent to having a terminal illness. In fact, in recent years, the neurology team of the Third Hospital of Sun Yat-sen has been researching and exploring, and has achieved preliminary results.
Director Qiu's team administered protein A immunoadsorbent disease to a patient who was diagnosed with "stiff person syndrome" in 2020, followed by immunosuppressants**.
It is understood that the patient has received 6 times of immunosorbent**. After the first immunoadsorption**, the patient's gait was significantly more stable and his muscles were relatively relaxed. With the end of subsequent immunoadsorption**, the patient's stiffness and mobility impairment in both lower extremities improved. At present, the patient is still persisting, and his life has basically returned to a normal state.
Tips: If you unfortunately have stiff legs and torso, unable to walk normally, and ankylosing spondylitis and other causes have been ruled out, it is recommended to go to the neurology department for relevant examination and intervention as soon as possible**.