Chinese name: active ester polyethylene glycol polylactic acid.
Product Name: pla-peg-nhs
Synonyms: NHS-PEG-PLA
Purity: 95%.
Molecular weight: 1k, 2k, 34K, 5K, 10K, 20K (can be customized on demand).
Status: Due to the different molecular weights of PEG, the product state is mostly liquid or viscous solid.
Solubility: Soluble in most organic solvents, such as: DCM, DMF, DMSO, THF, etc. It has good solubility in water.
Uses: Only for scientific research, not for human body.
Polylactic acid polyethylene glycol active ester (PLA-PEG-NHS) is a biodegradable polymer material widely used in the biomedical field. It is made by linking polylactic acid (PLA) and polyethylene glycol (PEG) through active ester bonds. This material has good biocompatibility and biodegradability, so it has a wide range of applications in the fields of drug delivery, tissue engineering, and biomedical diagnostics.
In terms of drug delivery, PLA-PEG-NHs can act as a drug carrier, encapsulating the drug in it to form drug nanoparticles or drug micelles. These drug carriers have high stability, which can protect the drug from the degradation of enzymes in the body, and at the same time can realize the targeted delivery of the drug, improve the efficacy of the drug and reduce the quality of the drug
In tissue engineering, PLA-PEG-NHS can be used as a biological scaffold material to provide a surface for cells to grow and attach. This material has good biocompatibility and is able to interact with cells to promote cell adhesion and proliferation. At the same time, PLA-PEG-NHS also has good degradability, which can be gradually degraded and metabolically excreted in the body, avoiding the problem of long-term retention of traditional non-degradable materials in the body.
In biomedical diagnostics, PLA-PEG-NHS can be used as a imaging agent or labeling agent for imaging or tracking in vivo. For example, it can be combined with fluorophores to form fluorescent nanoparticles for optical imaging or fluorescence tracingIt can also be combined with radioisotopes to form radiolabels for radioimaging or radiation**.