Potassium tert-butoxide is an organometallic compound with the following basic properties:
Common name: potassium tert-butoxide.
English name: potassium t-butoxide
CAS Number: 865-47-4
Molecular weight: 11221
Chemical Formula: Kotbu
Molar mass: approx. 11225 g moles.
Appearance: The common form is a white to yellowish solid.
Solubility: Potassium tert-butoxide is soluble in many organic solvents such as ether, toluene, and dimethyl sulfoxide, but only slightly soluble in water.
Uses: It is often used as an alkali catalyst in organic synthesis to promote the dehydroxylation reaction of alcohols and phenols, as well as other alcohol-related reactions.
Safety Precautions: Since potassium tert-butoxide reacts with water to release heat and produce hydrogen, care needs to be taken to avoid humid environments when handling and to guard against possible fire and ** risks.
Potassium tert-butoxide has a variety of uses in the field of chemistry, including but not limited to the following:
1.Base catalysts: Potassium tert-butoxide is often used as a strong base catalyst, especially in organic synthesis reactions. It can promote the dehydroxyl reactions of alcohols and phenols, such as in the dehydration and cleavage reaction of alcohols, the synthesis of ethers, and other alcohol-related reactions.
2.Organometallic chemistry: Potassium tert-butoxide can also be used in organometallic chemical reactions, such as as as as an alkali agent in the reaction of alkyl lithium and alkyl magnesium reagents.
3.Heterocyclic compound synthesis: It can also be used to prepare many heterocyclic compounds, such as pyridine, furan, etc.
4.Biomedicine: In some organic synthesis reactions, potassium tert-butoxide may be used to prepare bioactive molecules or pharmaceutical intermediates.
In summary, potassium tert-butoxide has a wide range of applications in organic synthesis, organometallic chemistry, and some specific biomedical fields.
As an important organometallic compound, potassium tert-butoxide is involved in both upstream and downstream products in its production and application. The following are some of the possible upstream and downstream products related to potassium tert-butoxide:
Upstream Products:**
1.Tert-butanol: Tert-butanol is one of the raw materials for the preparation of potassium tert-butanol.
2.Sodium metal: used in the reaction to generate sodium tert-butanol.
Downstream Products:**
1.Organic synthesis intermediates: Potassium tert-butoxide can be used in organic synthesis reactions to produce various organic molecules, some of which may be used as intermediates in pharmaceuticals or materials.
2.Other organometallic compounds: Potassium tert-butoxide can also play a role as an organometallic reagent in other organometallic synthesis reactions to produce various organometallic compounds.
These upstream and downstream products form the chain of chemicals associated with the production and application of potassium tert-butoxide.
Potassium tert-butoxide can usually be synthesized by the following synthetic routes:
1.Preparation of sodium tert-butanol: First, tert-butanol is reacted with sodium metal to produce sodium tert-butanol.
2.Sodium tert-butoxide reacts with potassium chloride: Sodium tert-butoxide is reacted with potassium chloride to produce a double rebalance reaction of potassium tert-butoxide and sodium chloride.
3.Extraction and purification: The product is extracted and purified to obtain a pure potassium tert-butoxide solid product.
This is a common industrial synthesis route for the large-scale production of potassium tert-butoxide. The synthesis process needs to be carried out in an inert atmosphere, as potassium tert-butoxide easily reacts with moisture and oxygen in the air.
Potassium tert-butoxide requires special care during transportation and storage as it is somewhat dangerous. Here are some common shipping and storage recommendations:
Shipping:**1Potassium tert-butoxide should be transported in a sealed, moisture-proof container.
2.Transport vehicles should be equipped with corresponding safety facilities to prevent accidental leakage or other accidents.
Storage: **1Potassium tert-butoxide should be stored in a dry, well-ventilated environment, away from fire and high temperatures.
2.The storage area should be kept away from water sources and acidic substances to prevent reactions with water or acids to produce harmful gases.
In all cases, potassium tert-butoxide should be transported and stored in accordance with relevant regulations and safety guidelines, and appropriate safety measures should be taken when handling this compound to ensure the safety of oneself and others.
The following precautions need to be followed when using potassium tert-butoxide:
1.Personal Protective Equipment: When handling potassium tert-butoxide, wear chemical protective glasses, protective gloves, and a lab coat to protect ** and eyes from contact with potassium tert-butoxide.
2.Good Ventilation: When using potassium tert-butoxide, ensure that the operating environment is well ventilated to prevent its vapor concentration from being too high.
3.Avoid humid environments: Potassium tert-butoxide is very sensitive to moisture, so humid environments should be avoided as much as possible during handling and storage.
4.Emergency measures: After accidental exposure to potassium tert-butoxide, rinse the affected area with plenty of water immediately and seek professional medical help.
5.Storage safety: Store potassium tert-butoxide away from flammable materials, oxidants and acids, and set up obvious warning signs in the storage area.
6.*Handling Caution: Care should be taken when handling potassium tert-butoxide to avoid dust, vapor or fog. Wash your hands promptly after operation and avoid accidental ingestion or inhalation.
In all cases, potassium tert-butoxide should be handled and used in accordance with relevant regulations and safe operating procedures to ensure the safety of oneself and others.