As a new type of non-steroidal anti-inflammatory drug, celecoxib can be used to control the symptoms of rheumatoid arthritis, and is a highly selective cyclooxygenase COX-2 inhibitor in the mechanism of action, which achieves anti-inflammatory and analgesic effects by inhibiting the production of prostaglandins, and has superior safety for the gastrointestinal tract.
First, celecoxib inhibits the synthesis of prostaglandins by the kidneys, which may induce edema and hypertension.
Second, celecoxib-specific COX-2 inhibitors do not affect the synthesis of thromboxane A2, so for people with a tendency to cardiovascular or cerebrovascular diseases, they may induce cardiovascular diseases such as thrombosis and hypertension, and long-term use of celecoxib may increase the risk of severe cardiovascular thrombotic adverse events, myocardial infarction, and stroke, which may be fatal.
Third, when using celecoxib, be alert to symptoms and signs such as chest pain, shortness of breath, weakness, and slurred speech, and stop taking the drug immediately when these symptoms or signs are present.
Fourth, celecoxib may also cause severe allergies and other *** sulfonamide allergy patients should use celecoxib with caution, and patients with sulfonamide allergy are also prone to celecoxib allergy.
Therefore, if patients need to use celecoxib, they must follow the doctor's instructions and cannot use it without authorization, but this kind of drug can only relieve symptoms and can take effect quickly, but it cannot control the condition of rheumatoid, so it is also necessary to improve the condition in combination with antirheumatic drugs **rheumatoid arthritis.