Beauty is the eternal pursuit of human beings. With the popularization of self-emergence and new-mindedness, today's society has entered the era of "national face-showing", and beauty-loving women pay more attention to their own facial status. However, due to changes in the environment and the rhythm of life, many beauty seekers find that their ** state has deteriorated, and problems such as fine lines, pores, pigmentation, and uneven skin tone have begun to appear, and even suddenly "collapsed face", this is because **aging is quietly occurring. The main causes of aging are decreased cell viability in tissues, decreased collagen fiber synthesis and elastic fiber degeneration, resulting in wrinkles, sagging and sagging.
With the development of regenerative medicine, a variety of technologies have been developed to improve aging. Among them, platelet-rich plasma (PRP)** has gradually attracted the attention of experts in the field of aesthetic medicine due to its good efficacy and safety. PRP is a platelet concentrate obtained by centrifuging autologous whole blood, which is rich in a variety of growth factors, which can promote cell proliferation and differentiation, stimulate collagen regeneration, promote matrix synthesis and remodeling, and the proportion of various growth factors in PRP is consistent with the normal proportion in vivo, with the best synergistic effect [1-2], and finally achieve ** renewal and improve ** quality.
Because PRP originates from autologous blood, it presents a faint golden yellow color after preparation, and PRP brings together a variety of bioactive substances in one, which is an endogenous regeneration, so PRP is also known as "autologous" regeneration, and is also known as "vampire" in foreign countries. Effect. At the same time, PRP** has small adverse reactions and easy access, and has become the new favorite of facial rejuvenation**.
Swiss Ruizhen PRP
Mechanism of action of PRP facial rejuvenation
1. Directly promote ** renewal and collagen deposition
PRP can activate the proliferation of dermal fibroblasts and mesenchymal stem cells, promote the secretion of endogenous HA and collagen, improve the quality, and adjust the ratio of collagen and collagen, which has a positive effect on preventing and alleviating scarring.
2. Promote vascular formation and tissue regeneration
The growth factors in PRP can stimulate the growth and migration of vascular endothelial cells, thereby inducing angiogenesis and promoting the formation of vascular-like tubular structures, which play a direct or key role in promoting angiogenesis and re-epithelialization.
3. Regulate inflammatory response
A variety of anti-inflammatory factors in PRP play an important role in the regulation of inflammation and help reduce the degree of non-infectious inflammation, thereby reducing erythema and edema.
2. Indications for PRP facial rejuvenation
Wrinkles [4].
One study included 20 women aged 40 to 49 years with aging face**, all of whom received PRP** (multiple points of injection of 2 ml of PRP into the facial dermis). After one month, the wrinkles on the patient's forehead and around the eyes improved significantly.
Melasma [5].
A 27-year-old female patient with melasma on the cheeks, periorbitals, and forehead for about 5 years underwent facial PRP** (Will15ml of PRP was injected into the dermal papilla layer of the face with an interval of 15 days, a total of 3 injections). After 3 PRP injections, the results were noticeable, and facial pigmentation was reduced by 80%.
Acne scarring [6].
One study included 30 patients with atrophic acne scars. **Group patients received fractional CO2 laser + PRP** (intradermal injection of PRP and facial application after laser **, once a month, a total of 3 times). After 3 sessions**, the patient's scar depth, redness, and pigmentation were significantly improved, while the duration of complications such as facial erythema, edema, and crusting after laser surgery was significantly reduced.
Periorbital hyperpigmentation [7].
In one study, 32 patients with periorbital pigmentation received a fractional ER:YAG laser + PRP** in the right periorbital area (after the laser**, PRP was injected into the periorbital region for a total of 3 times). After 3 times**, the patient's periorbital melanin content and **color difference were significantly reduced, while the skin tone and wrinkles were also improved.
Facial depression [8].
A retrospective study of 12 patients with facial asymmetry who underwent PRP combined with autologous fat particle transplantation** (injection filling after mixing PRP and adipocytes). *No complications such as induration, cysts, infection, scarring, or unevenness were observed, and patient satisfaction was 90%.
3. PRP preparation process
PRP is a blood-related product, and the preparation process needs to strictly comply with aseptic operation, and at the same time, according to the provisions of China's 2018 "Medical Device Classification Catalog", the PRP preparation kit is listed as a medical device for management.
Ruizhen PRP is a medical device imported from Switzerland, containing patented cell separation gel, a single tube of blood collection 8ml can obtain 4-5ml PRP at a centrifugation, the whole operation process is a one-step closed-loop operation, greatly reducing the risk of contamination.
4. Precautions for PRP**
Contraindications to PRP**: Patients with platelet dysfunction syndrome, severe thrombocytopenia, systemic sepsis, injected local infection, unwillingness to accept blood products** risk, definite psychological illness, or high expectations for ** should not undergo PRP**.
Adverse reactions of PRP facial injection: slight pain, erythema, bruising, mild edema, all adverse reactions disappeared within a few days;Individual patients have a burning sensation after injection, which can be improved by using a cold compress with a medical dressing;In addition to mild tenderness, early adverse reactions may also include facial tightness and dryness, and medical dressings can be used to hydrate within 1 week after PRP**Sun protection is required after PRP**.
PRP "autologous" regeneration** uses its own blood to prepare plasma rich in high concentration of growth factors, injects it into ** tissue, ensures its biological activity, uses its own strength to produce a large amount of collagen and elastic fibers, repairs damaged **, and restores **delicate luster, elasticity and firmness of youth.
References: 1] Kim DH, Je YJ, Kim CD, Lee YH, Seo YJ, Lee JH, et al can platelet-rich plasma be used for skin rejuvenation? evaluation of effects of platelet-rich plasma on human dermal fibroblast. ann dermatol. 2011;23:424–431.
2]cho jw, kim sa, lee ks. platelet-rich plasma induces increased expression of g1 cell cycle regulators, type i collagen, and matrix metalloproteinase-1 in human skin fibroblasts. int j mol med. 2012;29:32–36.
3] Endogenous ** regeneration 2731854?fromtitle=Vampire**&fromid=2728807&fr=aladdin
4] abuaf ok, yildiz h, baloglu h, bilgili me, simsek ha, dogan b. histologic evidence of new collagen formulation using platelet rich plasma in skin rejuvenation: a prospective controlled clinical study. ann dermatol. 2016;28(6):718-724. doi:10.5021/ad.2016.28.6.718.
5]mutlu c[gf]327[/gf]ay[gf]131[/gf]rl[gf]131[/gf], ercan c[gf]327[/gf]al[gf]131[/gf]s[gf]327[/gf]kan , gu[gf]308[/gf]rol ac[gf]327[/gf][gf]131[/gf]kgo[gf]308[/gf]z , ahmet hakan erbil , gu[gf]308[/gf]nes[gf]327[/gf]ertu[gf]308[/gf]rk. regression of melasma with platelet-rich plasma treatment. annals of dermatology 26(3):401-2.
6] galal o, tawfik aa, abdalla n, soliman m. fractional co2 laser versus combined platelet-rich plasma and fractional co2 laser in treatment of acne scars: image analysis system evaluation. j cosmet dermatol. 2019;18(6):1665-1671. doi:10.1111/jocd.12909.
7] nilforoushzadeh ma, heidari-kharaji m, al**i s, et al. assessing the effectiveness of the combination therapy with fractional er-yag laser and platelet-rich plasma in treatment of periorbital dark circles patients: a clinical trial. j cosmet dermatol. 2021;20(11):3526-3536. doi:10.1111/jocd.14036.
8] olba a m , nasr m .initial experience of face augmentation using fat graft-platlet rich plasma mix[j].surgical science, 2015, 6(11):489-498.doi:10.4236/ss.2015.611071.
9] Cheng Biao. Expert consensus on the application of platelet concentrate products in facial ** soft tissue rejuvenation (2020 edition)[J].Chinese Journal of Aesthetic Medicine, 2020, 29(10):6