Not long ago, good news came from the Affiliated Hospital of Qinghai University that Ma Ming (pseudonym), the first ** allogeneic hematopoietic stem cell transplant patient in Qinghai Province, was successfully released. The successful implementation of allogeneic hematopoietic stem cell transplantation is a breakthrough in the first allogeneic stem cell transplantation case in Qinghai Province, and it is also the highlight of the allogeneic stem cell transplantation technology in the Qinghai-Tibet Plateau, marking a major breakthrough in cutting-edge medical technology in Qinghai, Qinghai and other alpine regions
Technology promotes the development of medical care
The development of modern science and technology has injected a strong impetus into the development of medicine, thus promoting the rapid development of organ transplantation technology, which is known as the "top of modern medicine", and the success of organ transplantation technology has also become an important milestone in the history of modern medical development. In 1990, Murray and Thomas of the United States were jointly awarded the Nobel Prize in Physiology and Medicine for their important contributions to kidney transplantation and bone marrow transplantation, respectively, which was the first time that clinicians had received this honor. Hematopoietic stem cell transplantation is known as the "wonder" in the field of organ transplantation, and this technology has developed rapidly in the past two or three decades, providing new and effective technical methods for more than 60 kinds of stubborn diseases such as leukemia, aplastic anemia, congenital immunodeficiency, and malignant solid tumors. Bone marrow transplantation has become the first-line treatment for many malignant non-malignant diseases and hereditary diseases.
Development of stem cell transplantation technology
The first attempts at bone marrow transplantation began in the 30s of the 20th century, but it was limited to experiments and was not applied to clinical practice, and stem cell transplantation technology has developed rapidly in the following decades.In 1939, Rasjek and Osgood injected fresh bone marrow into the bone marrow and veins, respectively, for aplastic anemia.
In 1950, Lorenz et al. demonstrated that the infusion of the same bone marrow into mice after lethal irradiation could restore effective hematopoiesis.
Thomas discovered that the formed components of the graft survive and rebuild blood function in the bone marrow cavity of the recipient.
The most important discoveries in this field in the 60-70s of the last century were: transplant rejection and graft-versus-host disease (**HD).
Since the 70s of the 20th century, the discovery of the human leukocyte antigen (HLA) system, the application of new immunosuppressants, and the application of antibacterial, viral infection drugs and recombinant hematopoietic growth factors have greatly promoted the maturity of bone storage transplantation technology.
In the past 20 years, well-known bone marrow transplant cooperation organizations such as the International Bone Marrow Transplant Registry (IBMTR) and the European Collaboration Group on Blood and Marrow Transplantation (EBMTG) have been established, which have played an important role in promoting the basic research and clinical promotion of bone marrow transplantation worldwide, as well as the statistical analysis of bone marrow transplant results and prognosis.
The application of stem cell transplantation technology in plateau areas is of great significance
In recent years, various medical units in Qinghai Province have actively introduced teams and technologies in this field, and the hematopoietic stem cell transplantation team represented by the hematology team of the Affiliated Hospital of Qinghai University has become the core strength of hematology in the plateau region. Previously, the team has completed dozens of autologous hematopoietic stem cell transplantation, and the smooth delivery of Ma Ming (pseudonym) allogeneic stem cell transplantation has opened the first development of allogeneic hematopoietic stem cell transplantation technology for blood diseases in Qinghai Province. The development of this technology in Qinghai not only means the progress and popularization of medical technology in Qinghai, but also means that the children of the plateau can enjoy high-quality medical services at the 'doorstep' without having to travel thousands of miles, effectively reducing the cost and burden of medical treatment for patients. It is also the successful practice of the healthy China strategy in the plateauIt is a profound portrayal of the concept of people's health as the center;It is a concentrated manifestation of China's rejuvenation in the health protection of the people in the plateau area!
Finally, it is hoped that more cutting-edge medical technologies will be carried out in Qinghai, ** and other areas with relatively backward medical technology, so as to provide more patients with high-quality medical services at the "doorstep".